Modular interneuron circuits control motion sensitivity in the mouse retina.
Modular interneuron circuits control motion sensitivity in the mouse retina.
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DOI：
10.1038/s41467-023-43382-0
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发表时间：
2023-11-27
影响因子：
16.6
通讯作者：
Zhu, Yongling
中科院分区：
文献类型：
--
作者：
Jo, Andrew;Deniz, Sercan;Cherian, Suraj;Xu, Jian;Futagi, Daiki;Devries, Steven H.;Zhu, Yongling
Neural computations arise from highly precise connections between specific types of neurons. Retinal ganglion cells (RGCs) with similar stratification patterns are positioned to receive similar inputs but often display different response properties. In this study, we used intersectional mouse genetics to achieve single-cell type labeling and identified an object motion sensitive (OMS) AC type, COMS-AC(counter-OMS AC). Optogenetic stimulation revealed that COMS-AC makes glycinergic synapses with the OMS-insensitive HD2p-RGC, while chemogenetic inactivation showed that COMS-AC provides inhibitory control to HD2p-RGC during local motion. This local inhibition, combined with the inhibitory drive from TH2-AC during global motion, explains the OMS-insensitive feature of HD2p-RGC. In contrast, COMS-AC fails to make synapses with W3(UHD)-RGC, allowing it to exhibit OMS under the control of VGlut3-AC and TH2-AC. These findings reveal modular interneuron circuits that endow structurally similar RGC types with different responses and present a mechanism for redundancy-reduction in the retina to expand coding capacity. Interneuron circuits in the retina allow structurally similar retinal ganglion cells to show different responses. Here the authors use an intersectional genetics approach to identify an object motion sensitive amacrine cell subtype in the mouse retina.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
5
作者：
Chen X;Choo H;Huang XP;Yang X;Stone O;Roth BL;Jin J
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影响因子：
8.8
作者：
Zhou F;Elzi DJ;Jayabal P;Ma X;Chiu YC;Chen Y;Blackman B;Weintraub ST;Houghton PJ;Shiio Y
通讯作者：
Shiio Y
影响因子：
64.8
作者：
Euler, T;Detwiler, PB;Denk, W
通讯作者：
Denk, W
影响因子：
16.2
作者：
Grimes, William N.;Zhang, Jun;Graydon, Cole W.;Kachar, Bechara;Diamond, Jeffrey S.
通讯作者：
Diamond, Jeffrey S.