Clinical and Immunological Study of 30 Cases With Both IgG and IgA Anti-Keratinocyte Cell Surface Autoantibodies Toward the Definition of Intercellular IgG/IgA Dermatosis.
Clinical and Immunological Study of 30 Cases With Both IgG and IgA Anti-Keratinocyte Cell Surface Autoantibodies Toward the Definition of Intercellular IgG/IgA Dermatosis.
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DOI：
10.3389/fimmu.2018.00994
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发表时间：
2018
影响因子：
7.3
通讯作者：
Ishii N
中科院分区：
文献类型：
--
作者：
Hashimoto T;Teye K;Hashimoto K;Wozniak K;Ueo D;Fujiwara S;Inafuku K;Kotobuki Y;Jukic IL;Marinović B;Bruckner A;Tsuruta D;Kawakami T;Ishii N
几个散发的情况下，直接和间接的免疫荧光研究同时检测IgG和伊加自身抗体的角质形成细胞表面，已报告主要在IgG/伊加天疱疮的名称。然而，对于这种情况还没有系统的研究。在这项研究中，我们从我们的5,000多例自身免疫性大疱病病例中收集了30例这种情况，这些病例是从其他机构咨询我们的诊断方法的，并总结了他们的临床和免疫学发现。在临床上，没有男性和女性的患病率，平均发病年龄为55.6岁，平均持续时间之前，这种情况被怀疑是18个月。患者临床表现为大疱性和脓疱性皮肤病变，优先在躯干和四肢，组织病理学表皮内脓疱和水疱伴中性粒细胞和嗜酸性粒细胞浸润。在免疫学上，ELISA经常检测到桥粒芯糖蛋白和桥粒芯淋蛋白的IgG和伊加自身抗体。从特征性的临床，组织病理学和免疫学特征，这是相当大的不同，从那些在经典的IgG型天疱疮，我们建议这种疾病作为一个新的疾病实体与细胞间IgG/伊加皮肤病（IGAD）的优先名称。这是伊加特迄今为止规模最大的一次研究。
Several sporadic cases, in which direct and indirect immunofluorescence studies simultaneously detected IgG and IgA autoantibodies to keratinocyte cell surfaces, have been reported mainly under the name of IgG/IgA pemphigus. However, there have been no systematic studies for this condition. In this study, we collected 30 cases of this condition from our cohort of more than 5,000 autoimmune bullous disease cases, which were consulted for our diagnostic methods from other institutes, and summarized their clinical and immunological findings. Clinically, there was no male–female prevalence, mean age of disease onset was 55.6 years, and mean duration before this condition was suspected was 18 months. The patients showed clinically bullous and pustular skin lesions preferentially on the trunk and extremities, and histopathologically intraepidermal pustules and blisters with infiltration of neutrophils and eosinophils. Immunologically, ELISAs frequently detected IgG and IgA autoantibodies to both desmogleins and desmocollins. From the characteristic clinical, histopathological, and immunological features, which are considerably different from those in classical IgG types of pemphigus, we propose this disease as a new disease entity with preferential name of intercellular IgG/IgA dermatosis (IGAD). This was the largest study of IGAD to date.
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影响因子：
7.7
作者：
Horns, Felix;Vollmers, Christopher;Quake, Stephen R.
通讯作者：
Quake, Stephen R.
影响因子：
6.5
作者：
Hashimoto, T;Kiyokawa, C;Nishikawa, T
通讯作者：
Nishikawa, T
影响因子：
10.3
作者：
Ishii, N;Yoshida, M;Hashimoto, T
通讯作者：
Hashimoto, T
影响因子：
10.3
作者：
Mentink, L. F.;de Jong, M. C. J. M.;Pas, H. H.
通讯作者：
Pas, H. H.
影响因子：
6.5
作者：
HASHIMOTO, T;OGAWA, MM;NISHIKAWA, T
通讯作者：
NISHIKAWA, T