Deciphering and reversing tumor immune suppression.
Deciphering and reversing tumor immune suppression.
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DOI：
10.1016/j.immuni.2013.07.005
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发表时间：
2013-07-25
期刊：
影响因子：
32.4
通讯作者：
Coukos G
中科院分区：
文献类型：
--
作者：
Motz GT;Coukos G
产生抗肿瘤免疫反应是一个多步骤的过程，由效应T细胞执行，可以识别和杀死肿瘤靶标。然而，肿瘤采用多种策略来减弱T细胞介导攻击的有效性。这是通过干扰有效免疫所需的几乎每一步来实现的，从解除抗原提呈细胞的管制，到在脉管系统中建立物理屏障以防止效应肿瘤排斥细胞归巢，以及通过募集和激活免疫抑制细胞（如骨髓源性抑制细胞（MDSCs）、耐受性单核细胞和T调节细胞（Tregs））来抑制效应淋巴细胞。在这里，我们回顾了肿瘤发挥免疫抑制的方式，并强调了寻求逆转这一现象并促进抗肿瘤免疫的新疗法。了解抗肿瘤免疫，以及它是如何被肿瘤破坏的，将最终导致免疫疗法的改进，延长患者的生存期。
Generating an anti-tumor immune response is a multi-step process that is executed by effector T cells that can recognize and kill tumor targets. However, tumors employ multiple strategies to attenuate the effectiveness of T cell-mediated attack. This is achieved by interfering with nearly every step required for effective immunity, from deregulation of antigen-presenting cells, to establishment of a physical barrier at the vasculature that prevents homing of effector tumor-rejecting cells, and through the suppression of effector lymphocytes through the recruitment and activation of immunosuppressive cells like myeloid-derived suppressor cells (MDSCs), tolerogenic monocytes and T regulatory cells (Tregs). Here, we review the ways in which tumors exert immune suppression and highlight the new therapies that seek to reverse this phenomenon and promote anti-tumor immunity. Understanding anti-tumor immunity, and how it becomes disabled by tumors, will ultimately lead to improved immune therapies and prolonged survival of patients.
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影响因子：
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