Oxidative metabolism in the myocardium in normal subjects during dobutamine infusion
Oxidative metabolism in the myocardium in normal subjects during dobutamine infusion
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正常受试者输注多巴酚丁胺期间心肌的氧化代谢
DOI:
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发表时间:
1993
期刊:
影响因子:
--
通讯作者:
J. Konishi
中科院分区:
文献类型:
--
作者:
N. Tamaki;Y. Magata;N. Takahashi;M. Kawamoto;T. Torizuka;Y. Yonekura;E. Tadamura;K. Okuda;S. Ono;R. Nohara;H. Kambara;J. Konishi
To assess the biventricular response of the clearance rate of carbon-11 acetate as an index of myocardial oxidative metabolism to increase in work-load, dynamic positron emission tomography was performed at rest and during dobutamine infusion in 14 normal subjects. The clearance rate constant (Kmono) of the left ventricular (LV) myocardium increased during dobutamine infusion (0.112±0.020 min−1 vs 0.065±0.015 min−1 at rest) (P<0.001) in proportion to the increase in the pressure-rate product. Kmono in the right ventricular (RV) myocardium also increased (0.080±0.018 min−1 vs 0.034±0.013 min−1 at rest) (P<0.001), with an excellent correlation with the LV Kmono (r=0.920). The fact that the increase in RV Kmono during dobutamine infusion was greater (158%±81%) than that in LV Kmono (79%±39%) (P < 0.005) indicates a greater increase in oxidative metabolism in the RV in response to inotropic stimulation in normal subjects.
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影响因子:
24
作者:
Brown,MA;Myears,DW;Bergmann,SR
通讯作者:
Bergmann,SR
影响因子:
37.8
作者:
Buxton,DB;Nienaber,CA;Luxen,A;Ratib,O;Hansen,H;Phelps,ME;Schelbert,HR
通讯作者:
Schelbert,HR
DOI:
--
发表时间:
1989
期刊:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子:
--
作者:
Walsh,MN;Geltman,EM;Brown,MA;Henes,CG;Weinheimer,CJ;Sobel,BE;Bergmann,SR
通讯作者:
Bergmann,SR
DOI:
--
发表时间:
1991
期刊:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子:
--
作者:
Gropler,RJ;Siegel,BA;Geltman,EM
通讯作者:
Geltman,EM
影响因子:
4.8
作者:
Schelbert,HR;Henze,E;Sochor,H;Grossman,RG;Huang,SC;Barrio,JR;Schwaiger,M;Phelps,ME
通讯作者:
Phelps,ME