Oxidative metabolism in the myocardium in normal subjects during dobutamine infusion

Oxidative metabolism in the myocardium in normal subjects during dobutamine infusion
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正常受试者输注多巴酚丁胺期间心肌的氧化代谢

DOI:
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发表时间:
1993
期刊:
European Journal of Nuclear Medicine
影响因子:
--
通讯作者:
J. Konishi
J. Konishi
中科院分区:
--
文献类型:
--
作者:
N. Tamaki;Y. Magata;N. Takahashi;M. Kawamoto;T. Torizuka;Y. Yonekura;E. Tadamura;K. Okuda;S. Ono;R. Nohara;H. Kambara;J. Konishi

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为了评估双心室反应的碳-11醋酸清除率作为心肌氧化代谢的指标,以增加工作负荷,动态正电子发射断层扫描在休息时,在多巴酚丁胺输液在14名正常人。多巴酚丁胺输注期间左心室(LV)心肌的清除率常数(Kmono)增加(0.112±0.020 min-1 vs 0.065±0.015 min-1)(P<0.001),与压力-速率乘积的增加成比例。右心室(RV)心肌的Kmono也增加(0.080±0.018 min-1 vs静息时0.034±0.013 min-1)(P<0.001),与LV Kmono具有良好的相关性(r=0.920)。多巴酚丁胺滴注时右心室Kmono的增加(158%±81%)大于左心室Kmono的增加(79%±39%)(P < 0.005),表明正常人右心室对正性肌力刺激反应时氧化代谢增加更大。
To assess the biventricular response of the clearance rate of carbon-11 acetate as an index of myocardial oxidative metabolism to increase in work-load, dynamic positron emission tomography was performed at rest and during dobutamine infusion in 14 normal subjects. The clearance rate constant (Kmono) of the left ventricular (LV) myocardium increased during dobutamine infusion (0.112±0.020 min−1 vs 0.065±0.015 min−1 at rest) (P<0.001) in proportion to the increase in the pressure-rate product. Kmono in the right ventricular (RV) myocardium also increased (0.080±0.018 min−1 vs 0.034±0.013 min−1 at rest) (P<0.001), with an excellent correlation with the LV Kmono (r=0.920). The fact that the increase in RV Kmono during dobutamine infusion was greater (158%±81%) than that in LV Kmono (79%±39%) (P < 0.005) indicates a greater increase in oxidative metabolism in the RV in response to inotropic stimulation in normal subjects.
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