Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma.
Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma.
复制标题
Wnt和HH信号通路之间的串扰。
DOI：
10.3390/ijerph15071442
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发表时间：
2018-07-09
影响因子：
--
通讯作者：
Tchounwou PB
中科院分区：
文献类型：
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作者：
Noubissi FK;Yedjou CG;Spiegelman VS;Tchounwou PB
基底细胞癌（BCC）是所有癌症中最常见的形式。BCC的护理成本是美国医疗保险人群中所有癌症中最高的之一。Hedgehog（Hh）信号通路的激活似乎是BCC发展的关键驱动力。涉及小鼠模型的研究已经提供了证据表明，胶质瘤相关癌基因（GLI）家族转录因子的激活是导致BCC的致瘤程序启动的关键步骤。在BCC中也观察到Wnt途径的激活。此外，在小鼠模型中，Wnt信号传导途径已被证明是Hh途径驱动的BCC发展所需的。已经在不同水平上观察到Wnt和Hh通路之间的交叉对话，但这些交叉对话的机制尚未完全了解。在这篇综述中，我们研究了BCC发展中Wnt和Hh信号之间的相互作用机制及其治疗的潜在相关性。最近的研究已经确定了胰岛素样生长因子2 mRNA结合蛋白1（IGF 2BP 1），Wnt/β-catenin信号传导的直接靶点，作为与GLI 1 mRNA结合并上调其水平和活性的因子。GLI 1的这种调节模式在BCC肿瘤发生中显得重要，并且可以在BCC的治疗中进行探索。
Basal cell carcinoma (BCC) is the most frequently occurring form of all cancers. The cost of care for BCC is one of the highest for all cancers in the Medicare population in the United States. Activation of Hedgehog (Hh) signaling pathway appears to be a key driver of BCC development. Studies involving mouse models have provided evidence that activation of the glioma-associated oncogene (GLI) family of transcription factors is a key step in the initiation of the tumorigenic program leading to BCC. Activation of the Wnt pathway is also observed in BCCs. In addition, the Wnt signaling pathway has been shown to be required in Hh pathway-driven development of BCC in a mouse model. Cross-talks between Wnt and Hh pathways have been observed at different levels, yet the mechanisms of these cross-talks are not fully understood. In this review, we examine the mechanism of cross-talk between Wnt and Hh signaling in BCC development and its potential relevance for treatment. Recent studies have identified insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), a direct target of the Wnt/β-catenin signaling, as the factor that binds to GLI1 mRNA and upregulates its levels and activities. This mode of regulation of GLI1 appears important in BCC tumorigenesis and could be explored in the treatment of BCCs.
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影响因子：
1.1
作者：
Weiss GJ;Tibes R;Blaydorn L;Jameson G;Downhour M;White E;Caro I;Von Hoff DD
通讯作者：
Von Hoff DD
影响因子：
11.5
作者：
Axelson, Michael;Liu, Ke;Pazdur, Richard
通讯作者：
Pazdur, Richard
影响因子：
2.7
作者：
Chiang, C;Swan, RZ;Dlugosz, AA
通讯作者：
Dlugosz, AA
影响因子：
120.7
作者：
Christenson, LJ;Borrowman, TA;Roenigk, RK
通讯作者：
Roenigk, RK
DOI：
10.1038/nrc2503
发表时间：
2008-10
期刊：
Nature reviews. Cancer
影响因子：
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作者：
通讯作者：
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