Host traits, lifestyle and environment are associated with human skin bacteria
Host traits, lifestyle and environment are associated with human skin bacteria
复制标题
宿主特征、生活方式和环境与人类皮肤细菌有关
DOI：
10.1111/bjd.20072
复制
发表时间：
2021
影响因子：
10.3
通讯作者：
Weidinger S
中科院分区：
文献类型：
--
作者：
Moitinho-Silva L;Boraczynski N;Emmert H;Baurecht H;Szymczak S;Schulz H;Haller D;Linseisen J;Gieger C;Peters A;Tittmann L;Lieb W;Bang C;Franke A;Rodriguez E;Weidinger S
背景人类皮肤为微生物共生体提供了多样化的生态系统。然而，影响皮肤-微生物群相互作用的因素仍然不够明确。我们的目标是调查寄主特征、生活方式和环境因素与两个德国人群皮肤细菌的主要关联模式。方法这是一项横断面研究，参与者来自两个基于人群的德国队列：PopGen(n=294)和KORA FF4(n=353)，总计1794个皮肤样本。对16S核糖体RNA(RRNA)基因的V1-V2区进行了序列测定。用群落(β多样性)和16S rRNA基因扩增序列变异(ASV)两个细菌水平进行相关性检验。结果我们验证了皮肤微生物区系与皮肤微环境、年龄、体重指数和性别的已知相关性。这些因素与PopGen中ASV的β多样性和丰度有关，这在KORA FF4中基本上是复制的。最耐人寻味的是，膳食中的大量营养素和总膳食能量与几种ASV有关。ASV还与吸烟、饮酒、皮肤酸碱度、皮肤类型、经皮水分流失、教育和几种环境暴露有关，包括在户外度过的时间。相关的ASV包括丙酸杆菌属的成员，CorynebacteriumandStaphylococcus.ConclusionsWe扩大了目前对与皮肤细菌群落相关的因素的理解。我们展示了饮食与皮肤细菌之间的联系。最后，我们假设，与单一的皮肤生理特征、生活方式和环境暴露相比，皮肤微环境和宿主生理将在更大程度上塑造皮肤细菌群落。
BackgroundThe human skin offers diverse ecosystems for microbial symbionts. However, the factors shaping skin–microbiome interactions are still insufficiently characterized. This contrasts with the broader knowledge about factors influencing gut microbiota.ObjectivesWe aimed to investigate major patterns of association of host traits, lifestyle and environmental factors with skin bacteria in two German populations.MethodsThis is a cross‐sectional study with 647 participants from two population‐based German cohorts, PopGen (n= 294) and KORA FF4 (n= 353), totalling 1794 skin samples. The V1–V2 regions of the 16S ribosomal RNA (rRNA) gene were sequenced. Associations were tested with two bacterial levels, community (beta diversity) and 16S rRNA gene amplicon sequence variants (ASVs).ResultsWe validated known associations of the skin microbiota with skin microenvironment, age, body mass index and sex. These factors were associated with beta diversity and abundance of ASVs in PopGen, which was largely replicated in KORA FF4. Most intriguingly, dietary macronutrients and total dietary energy were associated with several ASVs. ASVs were also associated with smoking, alcohol consumption, skin pH, skin type, transepidermal water loss, education and several environmental exposures, including hours spent outdoors. Associated ASVs included members of the generaPropionibacterium,CorynebacteriumandStaphylococcus.ConclusionsWe expand the current understanding of factors associated with the skin bacterial community. We show the association of diet with skin bacteria. Finally, we hypothesize that the skin microenvironment and host physiology would shape the skin bacterial community to a greater extent compared with a single skin physiological feature, lifestyle and environmental exposure.
登录
查看更多内容
影响因子：
6.4
作者：
Ross AA;Doxey AC;Neufeld JD
通讯作者：
Neufeld JD
影响因子：
5
作者：
Mitry, Patricia;Wawro, Nina;Linseisen, Jakob
通讯作者：
Linseisen, Jakob
皮肤微生物群和皮肤抗菌防御系统的各个方面抵抗局部皮肤清洁剂的急性治疗。
DOI：
10.1016/j.jid.2016.06.612
发表时间：
2016
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Two,AimeeM;Nakatsuji,Teruaki;Kotol,PaulF;Arvanitidou,Evangelia;Du-Thumm,Laurence;Hata,TissaR;Gallo,RichardL
通讯作者：
Gallo,RichardL
影响因子：
9.8
作者：
Baurecht H;Hotze M;Brand S;Büning C;Cormican P;Corvin A;Ellinghaus D;Ellinghaus E;Esparza-Gordillo J;Fölster-Holst R;Franke A;Gieger C;Hubner N;Illig T;Irvine AD;Kabesch M;Lee YA;Lieb W;Marenholz I;McLean WH;Morris DW;Mrowietz U;Nair R;Nöthen MM;Novak N;O'Regan GM;Psoriasis Association Genetics Extension;Schreiber S;Smith C;Strauch K;Stuart PE;Trembath R;Tsoi LC;Weichenthal M;Barker J;Elder JT;Weidinger S;Cordell HJ;Brown SJ
通讯作者：
Brown SJ
影响因子：
7.1
作者：
Willett, WC;Howe, GR;Kushi, LH
通讯作者：
Kushi, LH