The Cutaneous Microbiome and Aspects of Skin Antimicrobial Defense System Resist Acute Treatment with Topical Skin Cleansers.
The Cutaneous Microbiome and Aspects of Skin Antimicrobial Defense System Resist Acute Treatment with Topical Skin Cleansers.
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皮肤微生物群和皮肤抗菌防御系统的各个方面抵抗局部皮肤清洁剂的急性治疗。
DOI：
10.1016/j.jid.2016.06.612
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Gallo,RichardL
中科院分区：
文献类型：
--
作者：
Two,AimeeM;Nakatsuji,Teruaki;Kotol,PaulF;Arvanitidou,Evangelia;Du-Thumm,Laurence;Hata,TissaR;Gallo,RichardL
人类皮肤微生物组被认为通过促进皮肤的先天防御在维持健康方面发挥着重要作用。这些观察结果激发了人们的猜测，即使用常见的皮肤清洗技术可能会通过改变微生物组而对表皮抗菌防御系统有害。在这项研究中，几种常见的皮肤清洁剂被用来清洗人类前臂，并测量了对抗菌肽LL-37丰度和细菌DNA丰度和多样性的短期影响。尽管洗涤后不久皮肤表面上LL-37的量有小但显著的减少，但没有检测到细菌群落的显著变化。此外，A组链球菌在洗涤后的皮肤上没有更好地存活。相比之下，在洗涤前向肥皂中加入抗菌化合物如苯扎氯铵或三氯卡班，可减少冲洗后应用的A组链球菌的生长。这些结果支持了先前的研究，即卫生保健环境中的洗手技术是有益的，应该继续下去。为了更好地了解长期洗涤的影响以及护肤品对某些个体生态失调发展的潜在影响，需要进行更多的研究。
The human skin microbiome has been suggested to play an essential role in maintaining health by contributing to innate defense of the skin. These observations have inspired speculation that the use of common skin washing techniques may be detrimental to the epidermal antibacterial defense system by altering the microbiome. In this study, several common skin cleansers were used to wash human forearms and the short-term effect on the abundance of the antimicrobial peptide LL-37 and the abundance and diversity of bacterial DNA was measured. Despite small but significant decreases in the amount of LL-37 on the skin surface shortly after washing, no significant change in the bacterial community was detected. Furthermore, Group AStreptococcusdid not survive better on the skin after washing. In contrast, the addition of antimicrobial compounds such as benzalkonium chloride or triclocarban to soap before washing decreased the growth of Group AStreptococcusapplied after rinse. These results support prior studies that hand washing techniques in the health care setting are beneficial and should be continued. Additional research is necessary to better understand the effects of chronic washing and the potential impact of skin care products on the development of dysbiosis in some individuals.
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影响因子：
--
作者：
CASEWELL, M;PHILLIPS, I
通讯作者：
PHILLIPS, I
减少医院相关轮状病毒感染：儿童医院的多学科手部卫生运动
DOI：
--
发表时间：
2005
期刊：
The Pediatric Infectious Disease Journal
影响因子：
--
作者：
D. Zerr;Amanda L Allpress;J. Heath;Rena Bornemann;E. Bennett
通讯作者：
E. Bennett
DOI：
10.1016/j.jid.2016.01.016
发表时间：
2016-05
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Meisel JS;Hannigan GD;Tyldsley AS;SanMiguel AJ;Hodkinson BP;Zheng Q;Grice EA
通讯作者：
Grice EA
影响因子：
4.9
作者：
Capretti, Maria Grazia;Sandri, Fabrizio;Faldella, Giacomo
通讯作者：
Faldella, Giacomo
影响因子：
7.8
作者：
Sanford JA;Gallo RL
通讯作者：
Gallo RL