Gray matter volumes and cognitive ability in the epileptogenic brain malformation of periventricular nodular heterotopia.
Gray matter volumes and cognitive ability in the epileptogenic brain malformation of periventricular nodular heterotopia.
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DOI：
10.1016/j.yebeh.2009.05.009
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Chang BS
中科院分区：
文献类型：
--
作者：
Walker LM;Katzir T;Liu T;Ly J;Corriveau K;Barzillai M;Chu F;O'Connor MG;Hackney DB;Chang BS
脑室周围结节性异位是一种以癫痫、智力正常和阅读障碍为特征的脑畸形。我们研究了这种疾病的脑容量和认知能力之间的结构-功能关系，通过研究12个PNH主题和6个控制使用体积分析的高分辨率解剖MRI和神经心理学测试。PNH受试者的总脑容量和特定脑室容量（灰质、白色物质和CSF）与对照组相当。异位灰质体积与皮质灰质体积呈负相关。与正常人不同，PNH患者的大脑和皮质体积与全面智商无关。我们的研究结果支持异位结节包含错位的神经元，通常会迁移到皮层的想法，并建议正常的认知能力的结构相关性可能是不同的神经元迁移失败的设置。
Periventricular nodular heterotopia (PNH) is a brain malformation clinically characterized by the triad of epilepsy, normal intelligence, and dyslexia. We investigated the structure-function relationship between cerebral volumes and cognitive ability in this disorder by studying twelve PNH subjects and six controls using volumetric analysis of high-resolution anatomical MRI and neuropsychological testing. Total cerebral volumes and specific brain compartment volumes (gray matter, white matter, and CSF) in PNH subjects were comparable to those in controls. There was a negative correlation between heterotopic gray matter volume and cortical gray matter volume. Cerebral and cortical volumes in PNH did not correlate with full-scale IQ, unlike in normal individuals. Our findings support the idea that heterotopic nodules contain misplaced neurons that would normally have migrated to the cortex, and suggest that structural correlates of normal cognitive ability may be different in the setting of neuronal migration failure.
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