Effect of long-term caffeine administration on depressive-like behavior in rats exposed to chronic unpredictable stress
Effect of long-term caffeine administration on depressive-like behavior in rats exposed to chronic unpredictable stress
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长期摄入咖啡因对慢性不可预测应激大鼠抑郁样行为的影响
DOI：
10.1097/fbp.0b013e3283564dd9
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发表时间：
2012
影响因子：
1.6
通讯作者：
K. Yakimova
中科院分区：
文献类型：
--
作者：
D. Pechlivanova;J. Tchekalarova;Liana H. Alova;V. Petkov;R. Nikolov;K. Yakimova
慢性不可预知的压力（CUS）被用来研究长期治疗的影响，咖啡因（8毫克/公斤，口服）或地昔帕明（dexipramine）（10毫克/公斤，腹腔注射）在Wistar大鼠。CUS程序应用6周。动物进行了为期2周的无药物CUS程序。药物与压力一起施用4周，并且药物和压力在整个行为测试期间都持续。暴露于DMSO的大鼠表现出抑郁样行为，体重增加减少，蔗糖溶液消耗减少，强迫游泳试验中的不动性增加，以及在开阔场地中的运动不足。对于旷场和高架十字迷宫，焦虑指数的计算证实，CUS增加焦虑，这是伴随着核心温度的增加。这些生理和行为上的变化都被抑制了。咖啡因对体重增加、运动活动、焦虑水平和核心温度产生了类似的影响。在暴露于咖啡因的大鼠中，咖啡因表现出抗抑郁和抗焦虑的活性，伴随着海马多巴胺和5-羟色胺水平的增加。然而，没有显着的变化，体重增加或核心温度后，观察咖啡因治疗暴露在大鼠。这些结果表明，类似于抗抑郁药，咖啡因长期暴露在CUS模型中发挥抗抑郁和抗焦虑作用。参与的多巴胺能和多巴胺能系统进行了讨论。
Chronic unpredictable stress (CUS) was used to study the effects of a long-term treatment with either caffeine (8 mg/kg, orally) or desipramine (DMI) (10 mg/kg, intraperitoneally) in Wistar rats. The CUS procedure was applied for 6 weeks. Animals underwent a 2-week drug-free CUS procedure. Drugs were administered for 4 weeks alongside the stress and both drug and stress were continued throughout the behavioral testing period. CUS-exposed rats showed depressive-like behavior with reduced weight gain, reduced consumption of sucrose solution, increased immobility in the forced swimming test, and hypolocomotion in an open field. For the open field and elevated plus maze, calculation of an anxiety index confirmed that CUS increased anxiety, which was accompanied by an increase in the core temperature. DMI counteracted these physical and behavioral changes. Caffeine caused similar effects to DMI on weight gain, motor activity, anxiety level, and core temperature. In CUS-exposed rats, caffeine showed antidepressant and anxiolytic activity, accompanied by increased hippocampal dopamine and serotonin levels. However, no significant change in weight gain or core temperature was observed after caffeine treatment in CUS-exposed rats. These results suggest that, similar to the antidepressant DMI, long-term caffeine exposure exerts an antidepressant and anxiolytic effect in the CUS model. The involvement of the dopaminergic and serotonergic systems is discussed.
影响因子：
21.1
作者：
B. Fredholm;K. Bättig;J. Holmén;A. Nehlig;E. Zvartau
通讯作者：
B. Fredholm;K. Bättig;J. Holmén;A. Nehlig;E. Zvartau
影响因子：
--
作者：
Ichiro Kawachi;W. C. Willett;G. Colditz;M. Stampfer;F. Speizer
通讯作者：
Ichiro Kawachi;W. C. Willett;G. Colditz;M. Stampfer;F. Speizer