Surface-Exposed Lipoproteins: An Emerging Secretion Phenomenon in Gram-Negative Bacteria.
Surface-Exposed Lipoproteins: An Emerging Secretion Phenomenon in Gram-Negative Bacteria.
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DOI：
10.1016/j.tim.2015.11.006
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发表时间：
2016-03
影响因子：
15.9
通讯作者：
Bernstein, Harris D.
中科院分区：
文献类型：
--
作者：
Wilson, Marlena M.;Bernstein, Harris D.
细菌脂蛋白是通过N-末端连接的脂肪酸锚定到细胞膜的亲水性蛋白质。人们普遍认为，革兰氏阴性菌产生的几乎所有脂蛋白要么保留在内膜（IM）中，要么转移到外膜（OM）的内小叶。暴露在细胞表面的脂蛋白也有报道，但通常被认为是罕见的。然而，最近各种研究的结果表明，表面暴露脂蛋白的流行被低估了。在这篇综述中，我们描述的证据表明，革兰氏阴性菌中的脂蛋白的表面暴露是一种普遍的现象，并讨论可能的机制，这些蛋白质可能被运送穿过OM。
Bacterial lipoproteins are hydrophilic proteins that are anchored to a cell membrane by N-terminally linked fatty acids. It is widely believed that nearly all lipoproteins produced by Gram-negative bacteria are either retained in the inner membrane (IM) or transferred to the inner leaflet of the outer membrane (OM). Lipoproteins that are exposed on the cell surface have also been reported, but are generally considered to be rare. Results from a variety of recent studies, however, now suggest that the prevalence of surface exposed lipoproteins has been underestimated. In this review we describe the evidence that the surface exposure of lipoproteins in Gram-negative bacteria is a widespread phenomenon and discuss possible mechanisms by which these proteins might be transported across the OM.
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影响因子：
3.1
作者：
DeRocco, Amanda J.;Cornelissen, Cynthia Nau
通讯作者：
Cornelissen, Cynthia Nau
影响因子：
3.1
作者：
CHAMBERLAIN, NR;BRANDT, ME;NORGARD, MV
通讯作者：
NORGARD, MV
影响因子：
11.4
作者：
DENFERT, C;RYTER, A;PUGSLEY, AP
通讯作者：
PUGSLEY, AP
影响因子：
3.6
作者：
DENFERT, C;CHAPON, C;PUGSLEY, AP
通讯作者：
PUGSLEY, AP
影响因子：
3.6
作者：
Cowles CE;Li Y;Semmelhack MF;Cristea IM;Silhavy TJ
通讯作者：
Silhavy TJ