Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway.
Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway.
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解替滨将人神经胶质瘤免疫敏感到通过FAS/FAS配体途径的NY-ESO-1特异性T淋巴细胞靶向。
DOI：
10.1186/1479-5876-9-192
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发表时间：
2011-11-07
影响因子：
7.4
通讯作者：
Prins RM
中科院分区：
文献类型：
--
作者：
Konkankit VV;Kim W;Koya RC;Eskin A;Dam MA;Nelson S;Ribas A;Liau LM;Prins RM
The lack of effective treatments for gliomas makes them a significant health problem and highlights the need for the development of novel and innovative treatment approaches. Immunotherapy is an appealing strategy because of the potential ability for immune cells to traffic to and destroy infiltrating tumor cells. However, the absence of well-characterized, highly immunogenic tumor-rejection antigens (TRA) in gliomas has limited the implementation of targeted immune-based therapies. We hypothesized that treatment with the demethylating agent, decitabine, would upregulate the expression of TRA on tumor cells, thereby facilitating enhanced surveillance by TRA-specific T cells. Treatment of human glioma cells with decitabine increased the expression of NY-ESO-1 and other well characterized cancer testes antigens. The upregulation of NY-ESO-1 made these tumors susceptible to NY-ESO-1-specific T-cell recognition and lysis. Interestingly, decitabine treatment of T98 glioma cells also sensitized them to Fas-dependent apoptosis with an agonistic antibody, while a Fas blocking antibody could largely prevent the enhanced functional recognition by NY-ESO-1 specific T cells. Thus, decitabine treatment transformed a non-immunogenic glioma cell into an immunogenic target that was efficiently recognized by NY-ESO-1--specific T cells. Such data supports the hypothesis that agents which alter epigenetic cellular processes may "immunosensitize" tumor cells to tumor-specific T cell-mediated lysis.
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影响因子：
11.2
作者：
Jazirehi AR;Baritaki S;Koya RC;Bonavida B;Economou JS
通讯作者：
Economou JS
影响因子：
3.9
作者：
Coral, S;Sigalotti, L;Maio, M
通讯作者：
Maio, M
影响因子：
37.3
作者：
Krakstad C;Chekenya M
通讯作者：
Chekenya M
影响因子：
4.4
作者：
Park, DR;Thomsen, AR;Liles, WC
通讯作者：
Liles, WC
DOI：
10.1073/pnas.94.5.1914
发表时间：
1997-03-04
影响因子：
11.1
作者：
Chen, YT;Scanlan, MJ;Old, LJ
通讯作者：
Old, LJ