MAOIs in adolescent major depression unresponsive to tricyclic antidepressants.

MAOIs in adolescent major depression unresponsive to tricyclic antidepressants.
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青少年重度抑郁症中的 MAOIs 对三环类抗抑郁药无反应。

DOI:
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发表时间:
1988
影响因子:
13.3
通讯作者:
D. Mazzie
D. Mazzie
中科院分区:
医学1区
文献类型:
--
作者:
N. Ryan;J. Puig;H. Rabinovich;J. Fried;P. Ambrosini;V. Meyer;D. Torres;S. Dachille;D. Mazzie

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摘要许多青少年抑郁症患者对标准三环类抗抑郁药的反应最多是部分反应,尽管剂量合适,治疗时间足够长。本文报告了一系列的23个这样的青少年谁是单胺氧化酶抑制剂(MAOIs)治疗。74%的人达到了良好或一般的抗抑郁反应,57%的人既有良好或一般的反应,又有持续的饮食依从性。几乎没有严重的副作用。必须特别注意MAOI治疗的受试者选择,因为存在冲动或意外饮食越轨的风险。这一回顾性图表综述强烈建议需要对三环类抗抑郁药难治性抑郁症青少年进行MAOI治疗的对照研究。
Abstract Many adolescents with major depressive disorder have at most partial response to standard tricyclic antidepressants despite appropriate dosage and adequate length of treatment. This paper reports a series of 23 such adolescents who were treated with monoamine oxidase inhibitors (MAOIs). Seventy-four percent of this group achieved good or fair antidepressant response, 57% had both good or fair response and continued dietary compliance. There were few serious side effects. Special attention must be paid to subject selection for treatment with MAOIs because of the risk of impulsive or accidental dietary transgression. This retrospective chart review strongly suggests the need for controlled studies of MAOI treatment in adolescents with tricyclic antidepressant refractory major depression.
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发表时间: 1985
影响因子: --
作者:
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影响因子: --
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