Additive Manufacturing and Physicomechanical Characteristics of PEGDA Hydrogels: Recent Advances and Perspective for Tissue Engineering.
Additive Manufacturing and Physicomechanical Characteristics of PEGDA Hydrogels: Recent Advances and Perspective for Tissue Engineering.
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PEGDA水凝胶的添加剂制造和物理力学特征：组织工程的最新进展和观点。
DOI：
10.3390/polym15102341
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发表时间：
2023-05-17
期刊：
影响因子：
5
通讯作者：
Aria AI
中科院分区：
文献类型：
--
作者：
Hakim Khalili M;Zhang R;Wilson S;Goel S;Impey SA;Aria AI
在这篇简短的综述中，我们讨论了聚（乙二醇）二丙烯酸酯（PEGDA）水凝胶用于组织工程应用的最新进展。PEGDA水凝胶由于其柔软和水合的性质，可以复制活组织，因此在生物医学和生物技术领域非常有吸引力。这些水凝胶可以使用光、热和交联剂来操作以实现期望的功能。与以前的综述不同，这些综述仅关注生物活性水凝胶的材料设计和制造及其细胞活力和与细胞外基质（ECM）的相互作用，我们将传统的批量光交联方法与最新的PEGDA水凝胶三维（3D）打印进行了比较。我们提供了详细的证据，结合了物理，化学，本体和局部机械特性，包括它们的组成，制造方法，实验条件和报告的本体和3D打印PEGDA水凝胶的机械性能。此外，我们强调了过去20年来3D PEGDA水凝胶在组织工程和器官芯片设备中的生物医学应用的现状。最后，我们深入研究了目前的障碍和未来的可能性，在工程领域的三维逐层（LBL）PEGDA水凝胶组织工程和器官芯片设备。
In this brief review, we discuss the recent advancements in using poly(ethylene glycol) diacrylate (PEGDA) hydrogels for tissue engineering applications. PEGDA hydrogels are highly attractive in biomedical and biotechnology fields due to their soft and hydrated properties that can replicate living tissues. These hydrogels can be manipulated using light, heat, and cross-linkers to achieve desirable functionalities. Unlike previous reviews that focused solely on material design and fabrication of bioactive hydrogels and their cell viability and interactions with the extracellular matrix (ECM), we compare the traditional bulk photo-crosslinking method with the latest three-dimensional (3D) printing of PEGDA hydrogels. We present detailed evidence combining the physical, chemical, bulk, and localized mechanical characteristics, including their composition, fabrication methods, experimental conditions, and reported mechanical properties of bulk and 3D printed PEGDA hydrogels. Furthermore, we highlight the current state of biomedical applications of 3D PEGDA hydrogels in tissue engineering and organ-on-chip devices over the last 20 years. Finally, we delve into the current obstacles and future possibilities in the field of engineering 3D layer-by-layer (LbL) PEGDA hydrogels for tissue engineering and organ-on-chip devices.
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影响因子：
4.6
作者：
Chan V;Park K;Collens MB;Kong H;Saif TA;Bashir R
通讯作者：
Bashir R
影响因子：
5
作者：
Argentiere S;Siciliano PA;Blasi L
通讯作者：
Blasi L
影响因子：
4.9
作者：
Bandyopadhyay, Ashutosh;Mandal, Biman B.;Bhardwaj, Nandana
通讯作者：
Bhardwaj, Nandana
DOI：
10.3390/molecules27134013
发表时间：
2022-06-22
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.7
作者：
Almasi, D.;Sharifi, R.;Kamarul, T.
通讯作者：
Kamarul, T.