Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients.
Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients.
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DOI：
10.1038/s41398-021-01553-x
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发表时间：
2021-09-01
影响因子：
6.8
通讯作者：
Woody M
中科院分区：
文献类型：
--
作者：
Price RB;Tervo-Clemmens BC;Panny B;Degutis M;Griffo A;Woody M
多巴胺能功能是一个关键的跨诊断神经生理学方面与精神病学的广泛相关性。标准化T2* 加权（nT 2 *w）成像先前已经被研究为量化纹状体中组织的生物学特性的方法（例如，组织铁），提供了一种广泛可用的、与多巴胺能功能潜在相关的体内标记物;但据我们所知，没有先前的研究在临床抑郁症中检查了这种神经成像标记物。在寻求治疗的临床抑郁样本（n = 110）中，我们定量了纹状体区域的组织铁（nT 2 *w）。我们评估了重测信度和相关值与不同分析水平的维度特征，包括人口统计学/生物学（性别，年龄，体重指数），神经解剖学（海马萎缩，使用最近验证的机器学习算法进行量化），以及与抑郁神经认知相关的基于性能（情感Go/NoGo任务性能）的指数。在患者中，纹状体区域组织铁浓度降低（以较高的nT 2 *w为指标）与情感Go/NoGo任务中认知情感功能降低的指标相关。更大的尾状核nT 2 *w也与更大的海马萎缩相关。女性患者的纹状体组织铁浓度明显低于男性，但性别差异并不能解释与其他神经认知变量的关系。一个广泛使用的功能磁共振成像指数纹状体组织的属性，表现出强大的心理测量特性，可以很容易地量化，从大多数功能磁共振成像数据集，无论研究的特定功能，如任务设计，表现出相关性的病理生理学的多个生物行为标志物的背景下，中度至重度，难治性抑郁症。纹状体组织铁可能在抑郁症的维度和亚组特异性特征中发挥作用，对未来抑郁症异质性研究具有启示意义。
Dopaminergic function is a critical transdiagnostic neurophysiological dimension with broad relevance in psychiatry. Normalized T2*-weighted (nT2*w) imaging has been previously investigated as a method to quantify biological properties of tissue in the striatum (e.g., tissue iron), providing a widely available, in vivo marker with potential relevance to dopaminergic function; but no prior study to our knowledge has examined this neuroimaging marker in clinical depression. In a treatment-seeking, clinically depressed sample (n = 110), we quantified tissue iron (nT2*w) in striatal regions. We assessed test-retest reliability and correlated values with dimensional features across levels of analysis, including demographic/biological (sex, age, Body Mass Index), neuroanatomical (hippocampal atrophy, which was quantified using a recently validated machine-learning algorithm), and performance-based (Affective Go/NoGo task performance) indices with relevance to depressive neurocognition. Across patients, decreased tissue iron concentration (as indexed by higher nT2*w) in striatal regions correlated with indices of decreased cognitive-affective function on the Affective Go/NoGo task. Greater caudate nT2*w also correlated with greater hippocampal atrophy. Striatal tissue iron concentrations were robustly lower in female patients than males but gender differences did not explain relations with other neurocognitive variables. A widely available fMRI index of striatal tissue properties, which exhibited strong psychometric properties and can be readily quantified from most fMRI datasets irrespective of study-specific features such as task design, showed relevance to multiple biobehavioral markers of pathophysiology in the context of moderate-to-severe, treatment-resistant depression. Striatal tissue iron may play a role in dimensional and subgroup-specific features of depression, with implications for future research on depression heterogeneity.
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