Diet adaptation in dog reflects spread of prehistoric agriculture.
Diet adaptation in dog reflects spread of prehistoric agriculture.
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DOI：
10.1038/hdy.2016.48
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发表时间：
2016-11
期刊：
影响因子：
3.8
通讯作者：
Axelsson, E.
中科院分区：
文献类型：
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作者：
Arendt, M.;Cairns, K. M.;Ballard, J. W. O.;Savolainen, P.;Axelsson, E.
使狗能够在富含淀粉的饮食中茁壮成长的适应，包括显着的 AMY2B 拷贝数增加，构成了狗从狼进化的关键一步。然而，尚不清楚这种变化是否与最初的驯化有关，或者代表与随后的农业发展相关的二次转变。之前研究这一过程的努力是基于地理上有限的数据集和低分辨率的方法，因此尚不清楚饮食适应在狗中的普遍程度，以及是否存在与人类替代生存策略相关的区域差异。在这里，我们使用液滴 PCR 来调查全球本土以及品种狗和狼之间的 AMY2B 拷贝数多样性，以阐明狗饮食的变化如何与驯化过程和随后的人类生存变化相关。我们发现 AMY2B 拷贝数呈双峰分布，在大多数狗中具有高拷贝数（中位数 2nAMY2B=11），但在一小群主要起源于澳大利亚和北极的狗中没有或很少有重复（中位数 2nAMY2B=3）。我们表明，这种模式在地理上与史前农业的传播相关，并得出结论，饮食变化可能与最初的驯化无关，而是与农业随后的发展和传播到全球大多数地区（但不是所有地区）有关。
Adaptations allowing dogs to thrive on a diet rich in starch, including a significant AMY2B copy number gain, constituted a crucial step in the evolution of the dog from the wolf. It is however not clear whether this change was associated with the initial domestication, or represents a secondary shift related to the subsequent development of agriculture. Previous efforts to study this process were based on geographically limited data sets and low-resolution methods, and it is therefore not known to what extent the diet adaptations are universal among dogs and whether there are regional differences associated with alternative human subsistence strategies. Here we use droplet PCR to investigate worldwide AMY2B copy number diversity among indigenous as well as breed dogs and wolves to elucidate how a change in dog diet was associated with the domestication process and subsequent shifts in human subsistence. We find that AMY2B copy numbers are bimodally distributed with high copy numbers (median 2nAMY2B=11) in a majority of dogs but no, or few, duplications (median 2nAMY2B=3) in a small group of dogs originating mostly in Australia and the Arctic. We show that this pattern correlates geographically to the spread of prehistoric agriculture and conclude that the diet change may not have been associated with initial domestication but rather the subsequent development and spread of agriculture to most, but not all regions of the globe.
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影响因子：
64.8
作者：
Lazaridis, Iosif;Patterson, Nick;Mittnik, Alissa;Renaud, Gabriel;Mallick, Swapan;Kirsanow, Karola;Sudmant, Peter H.;Schraiber, Joshua G.;Castellano, Sergi;Lipson, Mark;Berger, Bonnie;Economou, Christos;Bollongino, Ruth;Fu, Qiaomei;Bos, Kirsten I.;Nordenfelt, Susanne;Li, Heng;de Filippo, Cesare;Pruefer, Kay;Sawyer, Susanna;Posth, Cosimo;Haak, Wolfgang;Hallgren, Fredrik;Fornander, Elin;Rohland, Nadin;Delsate, Dominique;Francken, Michael;Guinet, Jean-Michel;Wahl, Joachim;Ayodo, George;Babiker, Hamza A.;Bailliet, Graciela;Balanovska, Elena;Balanovsky, Oleg;Barrantes, Ramiro;Bedoya, Gabriel;Ben-Ami, Haim;Bene, Judit;Berrada, Fouad;Bravi, Claudio M.;Brisighelli, Francesca;Busby, George B. J.;Cali, Francesco;Churnosov, Mikhail;Cole, David E. C.;Corach, Daniel;Damba, Larissa;van Driem, George;Dryomov, Stanislav;Dugoujon, Jean-Michel;Fedorova, Sardana A.;Romero, Irene Gallego;Gubina, Marina;Hammer, Michael;Henn, Brenna M.;Hervig, Tor;Hodoglugil, Ugur;Jha, Aashish R.;Karachanak-Yankova, Sena;Khusainova, Rita;Khusnutdinova, Elza;Kittles, Rick;Kivisild, Toomas;Klitz, William;Kucinskas, Vaidutis;Kushniarevich, Alena;Laredj, Leila;Litvinov, Sergey;Loukidis, Theologos;Mahley, Robert W.;Melegh, Bela;Metspalu, Ene;Molina, Julio;Mountain, Joanna;Nakkalajarvi, Klemetti;Nesheva, Desislava;Nyambo, Thomas;Osipova, Ludmila;Parik, Jueri;Platonov, Fedor;Posukh, Olga;Romano, Valentino;Rothhammer, Francisco;Rudan, Igor;Ruizbakiev, Ruslan;Sahakyan, Hovhannes;Sajantila, Antti;Salas, Antonio;Starikovskaya, Elena B.;Tarekegn, Ayele;Toncheva, Draga;Turdikulova, Shahlo;Uktveryte, Ingrida;Utevska, Olga;Vasquez, Rene;Villena, Mercedes;Voevoda, Mikhail;Winkler, Cheryl A.;Yepiskoposyan, Levon;Zalloua, Pierre;Zemunik, Tatijana;Cooper, Alan;Capelli, Cristian;Thomas, Mark G.;Ruiz-Linares, Andres;Tishkoff, Sarah A.;Singh, Lalji;Thangaraj, Kumarasamy;Villems, Richard;Comas, David;Sukernik, Rem;Metspalu, Mait;Meyer, Matthias;Eichler, Evan E.;Burger, Joachim;Slatkin, Montgomery;Paeaebo, Svante;Kelso, Janet;Reich, David;Krause, Johannes
通讯作者：
Krause, Johannes
影响因子：
10.7
作者：
Pang JF;Kluetsch C;Zou XJ;Zhang AB;Luo LY;Angleby H;Ardalan A;Ekström C;Sköllermo A;Lundeberg J;Matsumura S;Leitner T;Zhang YP;Savolainen P
通讯作者：
Savolainen P
影响因子：
30.8
作者：
Perry, George H.;Dominy, Nathaniel J.;Stone, Anne C.
通讯作者：
Stone, Anne C.
DOI：
10.1073/pnas.1217864110
发表时间：
2013-04-02
影响因子：
11.1
作者：
Liu, Li;Bestel, Sheahan;Chen, Xingcan
通讯作者：
Chen, Xingcan
来自阿尔泰山脉的尼安德特人的完整基因组序列。
影响因子：
64.8
作者：
通讯作者：
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