Antithymocyte globulin combined with cyclosporine A down-regulates T helper 1 cells by modulating T cell immune response cDNA 7 in aplastic anemia
Antithymocyte globulin combined with cyclosporine A down-regulates T helper 1 cells by modulating T cell immune response cDNA 7 in aplastic anemia
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抗胸腺细胞球蛋白联合环孢菌素 A 通过调节 T 细胞免疫反应 cDNA 7 下调再生障碍性贫血中 T 辅助细胞 1
DOI：
10.1007/s12032-015-0647-2
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发表时间：
2015-06
期刊：
影响因子：
3.4
通讯作者：
Xu Kailin
中科院分区：
文献类型：
--
作者：
Fu Chunling;Zeng Lingyu;Li Zhenyu;Xu Kailin
抗胸腺细胞球蛋白（ATG）联合环孢素A（CsA）治疗再生障碍性贫血（AA），尤其是重型再生障碍性贫血（SAA）已被广泛应用。T细胞异常活化可能是AA的免疫发病机制之一。T细胞免疫应答cDNA 7（TIRC 7）在T细胞活化中起重要作用，但TIRC 7在AA中的作用尚不清楚。在本研究中，我们记录了CsA组的TIRC 7水平仅在随访期高于ATG + CsA（AC）组SAA组TIRC 7水平在治疗期均高于非重型再生障碍性贫血组（P <0.05;P< 0.05）在随访期也有显著性差异（P <0.05;P< 0.01）。AC组和CsA组治疗前后辅助性T细胞（Th）1、Th 17和Th 22水平的变化趋势与TIRC 7水平的变化趋势相似。因此，TIRC 7可能参与了AA的发病过程，AC可能通过调节TIRC 7的表达下调Th 1细胞。
Antithymocyte globulin (ATG) combined with cyclosporine A (CsA) has been widely used as a standard regimen in the treatment of aplastic anemia (AA), especially in severe aplastic anemia (SAA). Abnormally activated T cells might be the immune pathogenesis of AA. T cell immune response cDNA 7 (TIRC7) has been demonstrated its essential role in T cell activation; however, little is known about the role of TIRC7 in AA. In this study, we documented that TIRC7 levels in CsA group were higher than that in ATG + CsA (AC) group only in the follow-up phase (P< 0.05;P< 0.05); nevertheless, TIRC7 levels in SAA group were elevated than non severe aplastic anemia group not only in the treatment phase (P< 0.05;P< 0.05) but also in the follow-up phase (P< 0.05;P< 0.01). The trend of changes of T helper (Th) 1, Th17 and Th22 levels before and after treatment was similar to the changes of TIRC7 levels in either AC group or CsA group. Thus, TIRC7 might be involved in the pathogenesis of AA and AC might down-regulate Th1 cells by modulating the expression of TIRC7 in AA.
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DOI：
10.1155/2013/513542
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
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作者：
Hsu HY;Kuan YC;Lin TY;Tsao SM;Hsu J;Ma LJ;Sheu F
通讯作者：
Sheu F
影响因子：
4.6
作者：
Utku, N;Heinemann, T;Blumberg, RS
通讯作者：
Blumberg, RS
影响因子：
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作者：
通讯作者：
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DOI：
10.1007/978-3-642-67483-9
发表时间：
1979
期刊：
[Rinsho ketsueki] The Japanese journal of clinical hematology
影响因子：
--
作者：
Kensuke Usuki
通讯作者：
Kensuke Usuki
影响因子：
20.3
作者：
de Latour, Regis Peffault;Visconte, Valeria;Young, Neal S.
通讯作者：
Young, Neal S.