A Comparison Study of the Effect on IBS-D Rats among Ginger-Partitioned Moxibustion, Mild Moxibustion, and Laser Moxibustion.
A Comparison Study of the Effect on IBS-D Rats among Ginger-Partitioned Moxibustion, Mild Moxibustion, and Laser Moxibustion.
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DOI：
10.1155/2021/4296216
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ji C
中科院分区：
文献类型：
--
作者：
Sun C;Yang X;Xie S;Zhou Z;Yu G;Feng S;Zhao J;Wu J;Ji C
腹泻型肠易激综合征（IBS-D）是一种严重影响患者生活的功能性胃肠疾病。莫西沙星被认为是治疗IBS-D的有效方法。然而，不同艾灸疗法对IBS-D的治疗效果及其机制尚不清楚。 将IBS-D模型大鼠分组，分别采用隔姜灸（GPM）、温和灸（MM）、43°C激光灸（LM）治疗。记录治疗过程中穴位的温度曲线。根据一般情况、大便情况、结肠组织苏木精-伊红染色评价疗效。此外，通过免疫组织化学方法分析了穴位组织和结肠组织中瞬时受体电位香草素1（TRPV 1）受体的表达。 经艾灸治疗后，症状改善。TRPV 1在穴位组织中表达增强，在结肠组织中表达减弱。GPM和MM对IBS-D大鼠的影响比LM更显著。GPM和MM的温度曲线呈波浪形，而LM的温度曲线几乎稳定。 GPM、MM、LM能改善IBS-D大鼠的症状。艾灸可激活穴位组织中TRPV 1通道，诱导穴位功能，从而抑制结肠TRPV 1的病理激活状态，改善腹痛和结肠炎症状。温度稳定的LM可能导致TRPV 1受体的脱敏和穴位耐受。GPM和MM提供动态和重复的热刺激，可能诱导穴位致敏，以增加疗效。因此，在艾灸的应用中，建议采用动态的、重复的热刺激。
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional gastrointestinal disorder that severely affects patients' life. Moxibustion is believed to be an effective way to treat IBS-D. However, the therapeutic effects and the underlying mechanisms in symptom management of IBS-D by different moxibustion therapies remain unclear. IBS-D model rats were divided into groups and treated with ginger-partitioned moxibustion (GPM), mild moxibustion (MM), and laser moxibustion (LM) at a temperature of 43°C, respectively. The temperature curves of acupoints were recorded during interventions. The therapeutic effects were evaluated on the basis of general condition, stool, and hematoxylin-eosin staining of the colon tissue. Moreover, the expression of transient receptor potential vanilloid 1 (TRPV1) receptors in both acupoint tissue and colon tissue was analyzed by immunohistochemistry. After moxibustion treatment, the symptoms were improved. The expression of TRPV1 was increased in acupoint tissue and decreased in colon tissue. GPM and MM showed a more significant influence on IBS-D rats compared with LM. The temperature profile of GPM and MM was wave-like, while LM had an almost stable temperature curve. GPM, MM, and LM could improve the symptoms in IBS-D rats. Moxibustion might activate TRPV1 channels in the acupoint tissue and induce acupoint functions, which in turn inhibit the pathological activation state of the colon's TRPV1, followed by improvements in abdominal pain and diarrheal symptoms. LM with stable temperature might lead to the desensitization of TRPV1 receptors and the tolerance of acupoint. GPM and MM provided dynamic and repetitive thermal stimulations that perhaps induced acupoint sensitization to increase efficacy. Therefore, dynamic and repetitive thermal stimulation is recommended in the application of moxibustion.
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影响因子：
7.6
作者：
Blake, M. R.;Raker, J. M.;Whelan, K.
通讯作者：
Whelan, K.
DOI：
10.1155/2013/379291
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Deng H;Shen X
通讯作者：
Shen X
影响因子：
--
作者：
Barbara, Giovanni;Cremon, Cesare;Corinaldesi, Roberto
通讯作者：
Corinaldesi, Roberto
影响因子：
24.5
作者：
Akbar A;Yiangou Y;Facer P;Walters JR;Anand P;Ghosh S
通讯作者：
Ghosh S
影响因子：
21.1
作者：
Gouin O;L'Herondelle K;Lebonvallet N;Le Gall-Ianotto C;Sakka M;Buhé V;Plée-Gautier E;Carré JL;Lefeuvre L;Misery L;Le Garrec R
通讯作者：
Le Garrec R