SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery.
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery.
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DOI：
10.1126/scitranslmed.abq3059
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发表时间：
2022-09-28
影响因子：
17.1
通讯作者：
Tenoever, Benjamin R.
中科院分区：
文献类型：
--
作者：
Frere, Justin J.;Serafini, Randal A.;Pryce, Kerri D.;Zazhytska, Marianna;Oishi, Kohei;Golynker, Ilona;Panis, Maryline;Zimering, Jeffrey;Horiuchi, Shu;Hoagland, Daisy A.;Moller, Rasmus;Ruiz, Anne;Kodra, Albana;Overdevest, Jonathan B.;Canoll, Peter D.;Borczuk, Alain C.;Chandar, Vasuretha;Bram, Yaron;Schwartz, Robert;Lomvardas, Stavros;Zachariou, Venetia;Tenoever, Benjamin R.
宿主对严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染的反应可导致长期病理，统称为COVID-19（PASC）或长期COVID的急性后后遗症。为了更好地理解长期COVID生物学的机制，我们比较了SARS-CoV-2或甲型流感病毒（IAV）感染后金仓鼠的短期和长期全身反应。结果表明，SARS-CoV-2在对肺和肾造成永久性损伤的能力方面超过了IAV，并且独特地影响了嗅球（OB）和上皮（OE）。尽管缺乏可检测的感染性病毒，OB和OE表现出骨髓和T细胞活化，促炎细胞因子的产生，以及与病毒清除后一个月的行为变化相关的干扰素反应。这些持续的转录变化也可以从从COVID-19康复者的组织中得到证实。这些数据强调了持续COVID-19病毒学的分子机制，并为探索未来的治疗方法提供了小动物模型。SARS-CoV-2感染导致神经系统持续炎症，是长期COVID的驱动因素。
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred to as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying long COVID biology, we compared the short- and long-term systemic responses in the golden hamster following either SARS-CoV-2 or influenza A virus (IAV) infection. Results demonstrated that SARS-CoV-2 exceeded IAV in its capacity to cause permanent injury to the lung and kidney and uniquely impacted the olfactory bulb (OB) and epithelium (OE). Despite a lack of detectable infectious virus, the OB and OE demonstrated myeloid and T cell activation, proinflammatory cytokine production, and an interferon response that correlated with behavioral changes extending a month post viral clearance. These sustained transcriptional changes could also be corroborated from tissue isolated from individuals who recovered from COVID-19. These data highlight a molecular mechanism for persistent COVID-19 symptomology and provide a small animal model to explore future therapeutics. SARS-CoV-2 infection results in sustained inflammation in the nervous system and is a driver of long COVID.
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DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
影响因子：
17.3
作者：
Aiyegbusi OL;Hughes SE;Turner G;Rivera SC;McMullan C;Chandan JS;Haroon S;Price G;Davies EH;Nirantharakumar K;Sapey E;Calvert MJ;TLC Study Group
通讯作者：
TLC Study Group
危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
4.6
作者：
Bankhead P;Loughrey MB;Fernández JA;Dombrowski Y;McArt DG;Dunne PD;McQuaid S;Gray RT;Murray LJ;Coleman HG;James JA;Salto-Tellez M;Hamilton PW
通讯作者：
Hamilton PW
影响因子：
16.2
作者：
Euston DR;Gruber AJ;McNaughton BL
通讯作者：
McNaughton BL