The role of medial prefrontal cortex in memory and decision making.

The role of medial prefrontal cortex in memory and decision making.
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DOI:
10.1016/j.neuron.2012.12.002
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发表时间:
2012-12-20
期刊:
影响因子:
16.2
通讯作者:
McNaughton BL
McNaughton BL
中科院分区:
医学1区
文献类型:
--
作者:
Euston DR;Gruber AJ;McNaughton BL

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一些人声称内侧前额叶皮质(mPFC)介导决策过程。另一些人则认为mPFC选择性地参与远期长期记忆的提取。还有一些人提出mPFC在从几秒到几天的时间尺度上对记忆和巩固起支持作用。如何协调所有这些作用呢?我们提出,mPFC的功能是学习情境、位置、事件以及相应的适应性反应(尤其是情绪反应)之间的关联。因此,mPFC在记忆和决策中普遍存在的参与可能是由于几乎所有此类任务都需要有能力回忆起在特定地点和时间对特定事件的最佳行动或情绪反应。多种记忆系统之间的相互作用可以解释mPFC随着时间推移对不同类型记忆的重要性变化。特别是,mPFC可能依赖海马体来支持快速学习和记忆巩固。
Some have claimed that the medial prefrontal cortex (mPFC) mediates decision making. Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet others suggests mPFC supports memory and consolidation on time-scales ranging from seconds to days. How can all these roles be reconciled? We propose that the function of the mPFC is to learn associations between context, locations, events, and corresponding adaptive responses, particularly emotional responses. Thus, the ubiquitous involvement of mPFC in both memory and decision making may be due to the fact that almost all such tasks entail the ability to recall the best action or emotional response to specific events in a particular place and time. An interaction between multiple memory systems may explain the changing importance of mPFC to different types of memories over time. In particular, mPFC likely relies on the hippocampus to support rapid learning and memory consolidation.
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