Serum inflammatory factors are positively correlated with the production of specific antibodies in coronavirus disease 2019 patients.
Serum inflammatory factors are positively correlated with the production of specific antibodies in coronavirus disease 2019 patients.
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DOI：
10.1038/s41423-020-00551-1
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发表时间：
2020-11
影响因子：
24.1
通讯作者：
Sun H
中科院分区：
文献类型：
--
作者：
Zheng M;Gao Y;Liu S;Sun D;Yang F;Zong L;Zhang M;Tian Z;Xu Y;Sun H
2019冠状病毒病（COVID-19）的持续传播构成了前所未有的国际关注。迄今为止，全球已确诊2300多万人感染COVID-19，该疾病已导致80多万人死亡。严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）引起的炎症反应过度已被报道有助于疾病的严重程度和死亡。1，2体液免疫应答在SARS-CoV-2感染的治疗和预防中起重要作用。由于SARS-CoV-2刺突（S）糖蛋白的受体结合结构域（RBD）与血管紧张素转换酶2结合，触发病毒粒子内吞作用，因此针对该结构域的抗体可能能够中和SARS-CoV-2，并可能为COVID-19患者提供保护性免疫。3目前正在进行研究恢复期血浆和白细胞介素（IL）-6拮抗剂托珠单抗治疗COVID-19患者的临床试验，4但抗体分泌细胞（ASC）的过度扩增可能在COVID-19患者中SARS-CoV-2的致病性中发挥重要作用。5因此，详细描述体液免疫应答和炎症因子之间的关系可以更好地理解COVID-19患者中SARS-CoV-2-宿主相互作用。在目前的研究中，RBD特异性IgG，RBD特异性伊加，ASCs和ICOS+滤泡辅助性T细胞（TFH）的频率在严重感染COVID的患者中更高，19例患者比非严重影响的患者。对COVID-19患者的随访分析表明，体液免疫应答与IL-6、CXC基序趋化因子10（CXCL 10）和C5 a的水平呈正相关。在COVID-19患者中，血清CXCL 13水平与IL-6和CXCL 10水平呈正相关。综上所述，这些结果表明体液免疫与炎症因子之间存在密切关系，保护性体液免疫的产生可能是COVID-19患者的双刃剑。
The ongoing spread of coronavirus disease 2019 (COVID-19) constitutes an international concern on an unprecedented scale. To date, over 23 million people have been diagnosed with COVID-19 worldwide, and this disease has caused more than 800,000 deaths. Hyperinflammation elicited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported to contribute to illness severity and death. 1, 2 Humoral immune responses play important roles in therapy and prophylaxis for SARS-CoV-2 infection. Since the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein binds to angiotensinconverting enzyme 2 to trigger virion endocytosis, antibodies against this domain may be able to neutralize SARS-CoV-2 and possibly provide protective immunity in COVID-19 patients. 3 Clinical trials investigating the administration of convalescent plasma and the interleukin (IL)-6 antagonist tocilizumab to treat COVID-19 patients are currently underway, 4 but the overly robust expansion of antibody-secreting cells (ASCs) could play a major role in the pathogenicity of SARS-CoV-2 in COVID-19 patients. 5 Thus, a detailed characterization of the associations between humoral immune responses and inflammatory factors could result in a better understanding of SARS-CoV-2-host interactions in COVID-19 patients.In the current study, the levels of RBD-specific IgG, RBD-specific IgA, and the frequencies of ASCs and ICOS+ T follicular helper (TFH) cells were found to be higher in severely affected COVID-19 patients than those in nonseverely affected patients. Follow-up analysis of COVID-19 patients demonstrated that humoral immune responses were positively correlated with the levels of IL-6, CXC motif chemokine 10 (CXCL10), and C5a. Positive correlations between the serum CXCL13 level and the levels of IL-6 and CXCL10 were also noted in COVID-19 patients. Taken together, these results indicate that there is a close relationship between humoral immunity and inflammatory factors, and the generation of protective humoral immunity could be a double-edged sword in COVID-19 patients.
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