Chemical effects in the separation process of a differential mobility/mass spectrometer system.
Chemical effects in the separation process of a differential mobility/mass spectrometer system.
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DOI：
10.1021/ac902571u
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发表时间：
2010-03-01
影响因子：
7.4
通讯作者：
Nazarov, Erkinjon G.
中科院分区：
文献类型：
--
作者：
Schneider, Bradley B.;Covey, Thomas R.;Coy, Stephen L.;Krylov, Evgeny V.;Nazarov, Erkinjon G.
在差分迁移率光谱法（DMS，也称为高场非对称波形离子迁移率光谱法，FAIMS）中，离子基于它们在高电场和低电场下的迁移率的差异而被分离。向传输离子通过DMS的气体中添加极性改性剂以依赖于场的方式增强了簇的形成，并因此放大了高和低场迁移率差异，导致峰值容量和分离能力增加。观察到的增加迁移率场的依赖性是一致的集群形成模型，也被称为动态集群decluster模型。在离子和形成团簇的中性物之间发生的化学相互作用的独特性增加了分离的选择性，并且相对于高场迁移率的低场迁移率的抑制增加了补偿电压和峰值容量。研究了极性改性剂对各种化学品峰容量的影响。我们讨论的理论基础，解释所观察到的效果。与极性改性剂的结果相反，我们发现使用惰性气体的混合物作为传输气体通过减小峰宽来提高分辨率，但对峰容量或选择性的影响很小。惰性气体不会聚集，因此相对于高场迁移率不会降低低场迁移率。当运输气体含有极性改性剂或含有大量惰性气体时，不同类别的化合物所表现出的微分迁移率α参数的变化可以根据分离过程中涉及的物理机制来解释。
In differential mobility spectrometry (DMS, also referred to as high field asymmetric waveform ion mobility spectrometry, FAIMS), ions are separated on the basis of the difference in their mobility under high and low electric fields. The addition of polar modifiers to the gas transporting the ions through a DMS enhances the formation of clusters in a field-dependent way and thus amplifies the high and low field mobility difference resulting in increased peak capacity and separation power. Observations of the increase in mobility field dependence are consistent with a cluster formation model, also referred to as the dynamic cluster-decluster model. The uniqueness of chemical interactions that occur between an ion and cluster-forming neutrals increases the selectivity of the separation and the depression of low-field mobility relative to high-field mobility increases the compensation voltage and peak capacity. The effect of polar modifiers on the peak capacity across a broad range of chemicals has been investigated. We discuss the theoretical underpinnings which explain the observed effects. In contrast to the result from polar modifiers, we find that using mixtures of inert gases as the transport gas improve resolution by reducing peak width but has very little effect on peak capacity or selectivity. Inert gases do not cluster and thus do not reduce low field mobility relative to high-field mobility. The observed changes in the differential mobility α parameter exhibited by different classes of compounds when the transport gas contains polar modifiers or has a significant fraction of inert gas can be explained on the basis of the physical mechanisms involved in the separation processes.
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差动迁移率质谱仪系统分离过程中化学效应的控制。
DOI：
10.1255/ejms.1025
发表时间：
2010
期刊：
European journal of mass spectrometry (Chichester, England)
影响因子：
--
作者：
Schneider BB;Covey TR;Coy SL;Krylov EV;Nazarov EG
通讯作者：
Nazarov EG
影响因子：
1.8
作者：
Krylov, E. V.;Nazarov, E. G.
通讯作者：
Nazarov, E. G.
DOI：
10.1016/0168-1176(93)87062-w
发表时间：
1993-10-29
期刊：
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES
影响因子：
--
作者：
BURYAKOV, IA;KRYLOV, EV;RASULEV, UK
通讯作者：
RASULEV, UK
影响因子：
2.8
作者：
Haber, LH;Husband, J;Leone, SR
通讯作者：
Leone, SR
影响因子：
7.4
作者：
Nazarov, Erkinjon G.;Coy, Stephen L.;Eiceman, Gary A.
通讯作者：
Eiceman, Gary A.