Control of chemical effects in the separation process of a differential mobility mass spectrometer system.
Control of chemical effects in the separation process of a differential mobility mass spectrometer system.
复制标题
差动迁移率质谱仪系统分离过程中化学效应的控制。
DOI：
10.1255/ejms.1025
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Nazarov EG
中科院分区：
文献类型：
--
作者：
Schneider BB;Covey TR;Coy SL;Krylov EV;Nazarov EG
差分迁移谱 (DMS) 根据离子在高电场和低电场下迁移速率的差异来分离离子。已经提出了描述这种场迁移率依赖性的物理性质的几种模型，但作为主导效应出现的是聚类模型，有时称为动态聚类-去聚类模型。 DMS 分辨率和峰容量受到修饰剂添加的强烈影响，修饰剂的添加会导致簇的形成和解离。由于离子和中性气相分子之间发生独特的化学相互作用，该过程提高了选择性。因此，必须控制影响化学相互作用的参数，并找到利用它们的方法，以提高设备的分析效用。在本文中，我们描述了为了稳定和利用主导 DMS 分离的化学过程而需要考虑的三个重要领域。第一个涉及用高浓度的特定试剂控制聚类反应的动态平衡的方法。第二个领域涉及一种处理电喷雾电离过程中发出的不需要的异质簇离子群的方法，这些离子群会降低分辨率和灵敏度。第三个涉及对影响基本碰撞过程、温度和压力的参数进行精细控制。
Differential mobility spectrometry (DMS) separates ions on the basis of the difference in their migration rates under high versus low electric fields. Several models describing the physical nature of this field mobility dependence have been proposed but emerging as a dominant effect is the clusterization model sometimes referred to as the dynamic cluster-decluster model. DMS resolution and peak capacity is strongly influenced by the addition of modifiers which results in the formation and dissociation of clusters. This process increases selectivity due to the unique chemical interactions that occur between an ion and neutral gas phase molecules. It is thus imperative to bring the parameters influencing the chemical interactions under control and find ways to exploit them in order to improve the analytical utility of the device. In this paper we describe three important areas that need consideration in order to stabilize and capitalize on the chemical processes that dominate a DMS separation. The first involves means of controlling the dynamic equilibrium of the clustering reactions with high concentrations of specific reagents. The second area involves a means to deal with the unwanted heterogeneous cluster ion populations emitted from the electrospray ionization process that degrade resolution and sensitivity. The third involves fine control of parameters that affect the fundamental collision processes, temperature and pressure.
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影响因子：
7.4
作者：
Robinson, Errol W.;Shvartsburg, Alexandre A.;Smith, Richard D.
通讯作者：
Smith, Richard D.
DOI：
10.1016/j.jasms.2006.10.008
发表时间：
2007-03-01
影响因子：
3.2
作者：
Levin, Daren S.;Vouros, Paul;Nazarov, Erkinjon G.
通讯作者：
Nazarov, Erkinjon G.
影响因子：
1.8
作者：
Krylov, E. V.;Nazarov, E. G.
通讯作者：
Nazarov, E. G.
DOI：
10.1016/0168-1176(93)87062-w
发表时间：
1993-10-29
期刊：
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES
影响因子：
--
作者：
BURYAKOV, IA;KRYLOV, EV;RASULEV, UK
通讯作者：
RASULEV, UK
影响因子：
7.4
作者：
Nazarov, Erkinjon G.;Coy, Stephen L.;Eiceman, Gary A.
通讯作者：
Eiceman, Gary A.