HMGB-1 as a novel predictor of disease severity and prognosis in patients with hemorrhagic fever with renal syndrome.
HMGB-1 as a novel predictor of disease severity and prognosis in patients with hemorrhagic fever with renal syndrome.
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HMGB-1 作为肾综合征出血热患者疾病严重程度和预后的新预测因子
DOI：
10.1155/2015/696248
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发表时间：
2015
影响因子：
4.6
通讯作者：
Wang P
中科院分区：
文献类型：
--
作者：
Du H;Li J;Yu H;Lian J;Zhang Y;Zhang Y;Bai X;Wang P
Objective.探讨高迁移率族蛋白-1（HMGB-1）对肾综合征出血热（HFRS）病情严重程度和预后的预测能力。方法.对105例HFRS患者和28例对照进行了研究。使用市售ELISA测量血液中HMGB-1的浓度。在同一时间段内常规检测白色细胞（WBC）、血小板（PLT）、红细胞压积（HCT）、白蛋白（ALB）、血尿素氮（BUN）、血肌酐（Scr）和尿酸（UA）水平。结果HMGB-1水平随病情加重而升高（P < 0.001）。HMGB-1与WBC、BUN呈正相关，与PLT、ALB、UA呈负相关（P < 0.001）。HMGB-1对预后的预测有统计学意义（AUC = 0.800，P < 0.001）。HMGB-1、WBC、PLT、ALB联合应用预测预后的敏感性和特异性均优于单独应用（AUC = 0.892，P < 0.001）。结论. HMGB-1可以被认为是HFRS患者严重程度和结局的新生物标志物。联合使用HMGB-1、WBC、PLT和ALB来预测HFRS患者的结局显示出可接受的诊断能力。
Objective. To examine the predictive capacity of the high mobility group box protein-1 (HMGB-1) for disease severity and prognosis of hemorrhagic fever with renal syndrome (HFRS). Methods. One hundred and five HFRS patients and 28 controls were studied. The concentrations of HMGB-1 in the blood were measured with a commercially available ELISA. The levels of white blood cells (WBC), platelets (PLT), hematocrit (HCT), albumin (ALB), blood urea nitrogen (BUN), serum creatinine (Scr), and uric acid (UA) were routinely tested in the same time frame. Results. The levels of HMGB-1 increased with the severity of the disease (P < 0.001). HMGB-1 was positively correlated with WBC and BUN and negatively correlated with PLT, ALB, and UA (P < 0.001). HMGB-1 showed statistical significance for predicting prognosis (AUC = 0.800, P < 0.001). The sensitivity and specificity of HMGB-1, WBC, PLT, and ALB used in combination for predicting outcome were better than those of single analyses (AUC = 0.892, P < 0.001). Conclusions. HMGB-1 can be considered a novel biomarker for severity and outcome in patients with HFRS. The use of HMGB-1, WBC, PLT, and ALB in combination to predict the outcome in patients with HFRS exhibited an acceptable level of diagnostic capability.
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