Serum albumin level correlates with disease severity in patients with Hemorrhagic Fever with Renal Syndrome.
Serum albumin level correlates with disease severity in patients with Hemorrhagic Fever with Renal Syndrome.
复制标题
血清白蛋白水平与肾脏综合征出血热患者的疾病严重程度相关。
DOI：
10.3346/jkms.2003.18.5.696
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发表时间：
2003-10
影响因子：
4.5
通讯作者：
Bang BK
中科院分区：
文献类型：
--
作者：
Kim YO;Yoon SA;Ku YM;Yang CW;Kim YS;Kim SY;Choi EJ;Chang YS;Bang BK
低蛋白血症常见于肾综合征出血热(HFRS)，但其临床意义尚不清楚。这项研究旨在评估低蛋白血症作为肾综合征出血热患者病情严重程度的标志。我们对144例肾综合征出血热患者的血清白蛋白水平与代表疾病严重程度的临床参数之间的关系进行了评估。根据血清白蛋白水平将患者分为3组：I组(正常血清白蛋白)、II组(血清白蛋白3.5g/dL)和III组(血白蛋白3.0g/dL)。其中I组42例(29.2%)，II组39例(27.1%)，III组63例(43.8%)。III组低血压、肺水肿发生率明显高于I组和II组，血清白蛋白水平与血小板计数呈正相关(r=0.505，p<；0.001)，与白细胞计数(r=-0.329，p<；0.001)、尿素氮(r=-0.484，p<；)呈负相关。0.001)、血肌酐(r=-0.394，p&t；0.001)和天冬氨酸转氨酶(r=-0.251，p=0.002)。提示肾综合征出血热急性期易发生低蛋白血症，血清白蛋白水平与病情严重程度相关。
Hypoalbuminemia frequently occurs in Hemorrhagic Fever with Renal Syndrome (HFRS), but clinical significance of hypoalbuminemia is not well known. This study was designed to evaluate hypoalbuminemia as a marker of severity of disease in patients with HFRS. We evaluated the relationship between the level of serum albumin and clinical parameters representing the severity of disease in 144 patients with HFRS. The patients were divided into three groups based on the level of serum albumin; Group I (normal serum albumin), Group II (serum albumin <3.5 g/dL and >/=3.0 g/dL), and Group III (serum albumin <3.0 g/dL). Of the total of 144 patients, 42 patients (29.2%) were categorized as Group I, 39 patients (27.1%) as Group II, and 63 patients (43.8%) as Group III. Group III had a higher rate of incidence in episode of hypotension, pulmonary edema than did Group I and Group II. The lowest level of serum albumin was positively correlated with platelet count (r=0.505, p<0.001) and was negatively correlated with leukocyte count (r=-0.329, p<0.001), BUN (r=-0.484, p<0.001), serum creatinine (r=-0.394, p<0.001), and AST (r=-0.251, p=0.002). Our data suggest that hypoalbuminemia frequently occurs in the acute stage of HFRS, and level of serum albumin is associated with the disease severity of HFRS.
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影响因子：
2.5
作者：
Mustonen, J;Mäkelä, S;Pasternack, A
通讯作者：
Pasternack, A
影响因子：
--
作者：
COHEN, MS;KWEI, HE;GE, HC
通讯作者：
GE, HC
影响因子：
1.3
作者：
Paakkala, A;Kallio, T;Mustonen, J
通讯作者：
Mustonen, J
DOI：
10.1007/s10096-003-0902-x
发表时间：
2003-03-01
影响因子：
4.5
作者：
Carratalà, J;Rosón, B;Gudiol, F
通讯作者：
Gudiol, F
影响因子：
5.9
作者：
SHEEDY, JA;FROEB, HF;YOE, RH
通讯作者：
YOE, RH