Staphylococcus aureus infections: transmission within households and the community.
Staphylococcus aureus infections: transmission within households and the community.
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DOI：
10.1016/j.tim.2015.03.007
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发表时间：
2015-07
影响因子：
15.9
通讯作者：
Lowy, Franklin D.
中科院分区：
文献类型：
--
作者：
Knox, Justin;Uhlemannl, Anne-Catrin;Lowy, Franklin D.
金黄色葡萄球菌对甲氧西林敏感和耐药，现在是全世界主要的社区病原体。这种情况的基础是多因素的，包括出现了具有增强的毒力、抗生素耐药性、定植潜力或传播性的流行病克隆。这些独特菌株的家庭宿主对于它们作为社区病原体的成功至关重要。葡萄球菌作为殖民者或环境污染物居住在家庭中，增加了复发感染的风险。家庭成员与其他人在不同家庭或在社区场所（包括学校和日托设施）的相互作用对这些菌株成为地方性疾病的能力起着关键作用。这些地点的定殖密度似乎在促进传播方面起着重要作用。包括全基因组测序、数学建模和社会网络分析在内的研究工具的整合为这些菌株的传播动态提供了额外的见解。到目前为止，旨在减少家庭成员之间复发感染的干预措施取得的成功有限，这可能是由于重新定植的潜在来源多种多样。制定更好的战略以减少家庭感染的数量将取决于更深入地了解促成这些独特成功的金黄色葡萄球菌流行病克隆成功的不同因素。
Staphylococcus aureus , both methicillin susceptible and resistant, are now major community-based pathogens worldwide. The basis for this is multifactorial and includes the emergence of epidemic clones with enhanced virulence, antibiotic resistance, colonization potential, or transmissibility. Household reservoirs of these unique strains are crucial to their success as community-based pathogens. Staphylococci become resident in households, either as colonizers or environmental contaminants, increasing the risk for recurrent infections. Interactions of household members with others in different households or at community sites including schools and daycare facilities play a critical role in the ability of these strains to become endemic. Colonization density at these sites appears to play an important role in facilitating transmission. The integration of research tools including whole genome sequencing, mathematical modeling and social network analysis have provided additional insight into the transmission dynamics of these strains. Thus far, interventions designed to reduce recurrent infections among household members have had limited success, likely due to the multiplicity of potential sources for recolonization. The development of better strategies to reduce the number of household-based infections will depend on greater insight into the different factors that contribute to the success of these uniquely successful epidemic clones of S. aureus.
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影响因子：
168.9
作者：
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