Effect of multimorbidity patterns on the decline in health-related quality of life: a nationwide prospective cohort study in Japan.
Effect of multimorbidity patterns on the decline in health-related quality of life: a nationwide prospective cohort study in Japan.
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DOI：
10.1136/bmjopen-2020-047812
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发表时间：
2021-06-14
期刊：
影响因子：
2.9
通讯作者：
Yamamoto Y
中科院分区：
文献类型：
--
作者：
Aoki T;Fukuhara S;Fujinuma Y;Yamamoto Y
纵向研究考虑了多发病模式，有助于更好地阐明多发病对健康相关生活质量 (HRQoL) 的影响，并有助于确定多发病患者中临床结果较差的目标人群。本研究旨在探讨不同的多重发病模式对 HRQoL 下降的影响。全国前瞻性队列研究。日本成年居民。采用定额抽样法抽取年龄≥50岁的居民。 HRQoL 的临床相关下降定义为 1 年 36 项简短健康调查 (SF-36) 组成部分总结分数下降 0.50 SD（5 分）。共有 1211 名参与者完成了后续调查。在使用验证性因素分析确定的多发病模式中，多变量逻辑回归分析显示，心血管/肾脏/代谢和恶性/消化/泌尿系统模式评分高与 SF-36 身体成分总结评分的临床相关下降显着相关（调整后 OR (aOR)=1.25，95% CI：1.08 至 1.44 和 aOR=1.28，95% CI：1.04 至分别为 1.58）。高心血管/肾脏/代谢模式评分也与 SF-36 角色/社会成分总结评分的临床相关下降显着相关（aOR=1.23，95%CI：1.06 至 1.42）。我们的研究表明，多种发病模式对 1 年临床相关 HRQoL 下降有不同的影响。这些发现有助于识别慢性病和多种疾病患者中的高危人群和临床结果不佳的人群，从而实现有效的资源分配。
Longitudinal studies, which consider multimorbidity patterns, are useful for better clarifying the effect of multimorbidity on health-related quality of life (HRQoL) and for identifying the target population with poorer clinical outcomes among patients with multimorbidity. This study aimed to examine the effects of different multimorbidity patterns on the decline in HRQoL. Nationwide prospective cohort study. Japanese adult residents. Residents aged ≥50 years selected by the quota sampling method. Clinically relevant decline in HRQoL was defined as a 0.50 SD (5-point) decrease in the 36-Item Short Form Health Survey (SF-36) component summary scores for 1 year. In total, 1211 participants completed the follow-up survey. Among the multimorbidity patterns identified using confirmatory factor analysis, multivariable logistic regression analyses revealed that high cardiovascular/renal/metabolic and malignant/digestive/urologic pattern scores were significantly associated with the clinically relevant decline in SF-36 physical component summary score (adjusted OR (aOR)=1.25, 95% CI: 1.08 to 1.44 and aOR=1.28, 95% CI: 1.04 to 1.58, respectively). High cardiovascular/renal/metabolic pattern score was also significantly associated with the clinically relevant decline in SF-36 role/social component summary score (aOR=1.23, 95% CI: 1.06 to 1.42). Our study revealed that multimorbidity patterns have different effects on the clinically relevant decline in HRQoL for 1 year. These findings can be useful in identifying populations at high risk and with poor clinical outcomes among patients with chronic diseases and multimorbidity for efficient resource allocation.
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DOI：
10.1097/00001648-199001000-00010
发表时间：
1990-01-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Rothman, K J
通讯作者：
Rothman, K J
DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
7.2
作者：
Fukuhara, S;Bito, S;Kurokawa, K
通讯作者：
Kurokawa, K
影响因子：
2.9
作者：
Harrison C;Britt H;Miller G;Henderson J
通讯作者：
Henderson J
影响因子：
9.3
作者：
Tran VT;Harrington M;Montori VM;Barnes C;Wicks P;Ravaud P
通讯作者：
Ravaud P