Efficacy of cooling therapy and α-lipoic acid derivative against chemotherapy-induced alopecia in an animal model.
Efficacy of cooling therapy and α-lipoic acid derivative against chemotherapy-induced alopecia in an animal model.
复制标题
作者：
化疗引起的脱发经常由各种化疗方案引起，对心理健康和生活质量有重大影响。然而，现有的治疗化疗引起的脱发的效果还不够。本研究旨在阐明皮肤冷却和抗氧化剂α-硫辛酸衍生物对化疗引起的脱发的治疗效果和机制。我们使用癌症研究所小鼠开发了环磷酰胺（120μg/g）化疗诱导的脱发模型。我们采用降温疗法和α-硫辛酸衍生物应用作为治疗方法。我们比较了对照组和治疗组之间的脱发评分、毛球直径、胰岛素样生长因子-1 水平、血管通透性和细胞凋亡。与环磷酰胺组相比，各治疗组的脱发评分均显着改善。与环磷酰胺组相比，环磷酰胺 + 冷却组的毛球直径显着改善。与环磷酰胺组相比，每个治疗组的胰岛素样生长因子-1水平和血管通透性水平分别显着保留和抑制。与环磷酰胺组相比，环磷酰胺+α-硫辛酸衍生物组血管内皮细胞凋亡细胞数显着减少。总之，降温疗法和α-硫辛酸衍生物通过降低血管通透性促进环磷酰胺引起的化疗引起的脱发的恢复。化疗引起的脱发经常由各种化疗方案引起，对心理健康和生活质量有重大影响。在这项研究中，我们证明冷却疗法和α-硫辛酸衍生物通过降低血管通透性促进环磷酰胺引起的化疗引起的脱发的恢复。
Chemotherapy‐induced alopecia is frequently induced by various regimens of chemotherapy and has a significant impact on mental health and quality of life. However, the effect of available current treatment for chemotherapy‐induced alopecia is not sufficient. This study aimed to clarify the therapeutic effects and mechanism of skin cooling and the antioxidant α‐lipoic acid derivative on chemotherapy‐induced alopecia. We developed a chemotherapy‐induced alopecia model of cyclophosphamide (120 μg/g) using Institute of Cancer Research mice. We used cooling therapy and α‐lipoic acid derivative application as the treatments. We compared the alopecia score, hair bulb diameter, insulin‐like growth factor‐1 level, vascular permeability, and apoptosis between the control and treatment groups. The alopecia score significantly improved in each treatment group compared with that in the cyclophosphamide group. Hair bulb diameter significantly improved in the cyclophosphamide + cooling group compared with that in the cyclophosphamide group. The insulin‐like growth factor‐1 level and vascular permeability level was significantly retained and suppressed, respectively, in each treatment group compared with that in the cyclophosphamide group. The number of apoptotic cells in the vascular endothelium significantly decreased in the cyclophosphamide + α‐lipoic acid derivative group compared with that in the cyclophosphamide group. In conclusion, cooling therapy and α‐lipoic acid derivative facilitated recovery from chemotherapy‐induced alopecia caused by cyclophosphamide through decreasing vascular permeability. Chemotherapy‐induced alopecia is frequently induced by various regimens of chemotherapy and has a significant impact on mental health and quality of life. In this study, we demonstrated that cooling therapy and a‐lipoic acid derivative facilitated recovery from chemotherapy‐induced alopecia caused by cyclophosphamide through decreasing vascular permeability.
登录
查看更多内容
DOI：
10.1111/j.1440-1746.2011.06773.x
发表时间：
2011-11-01
影响因子：
4.1
作者：
Masuda, Takashi;Iwashita, Yukio;Kitano, Seigo
通讯作者：
Kitano, Seigo
影响因子：
6.5
作者：
Weger, N;Schlake, T
通讯作者：
Schlake, T
影响因子：
13.8
作者：
Freites-Martinez A;Shapiro J;Goldfarb S;Nangia J;Jimenez JJ;Paus R;Lacouture ME
通讯作者：
Lacouture ME
影响因子：
6.5
作者：
Rudman, SM;Philpott, MP;Kealey, T
通讯作者：
Kealey, T
影响因子：
5.5
作者：
Hodges, Gary J.;Zhao, Kun;Johnson, John M.
通讯作者：
Johnson, John M.