Hair disorders in patients with cancer.

Hair disorders in patients with cancer.
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DOI:
10.1016/j.jaad.2018.03.055
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发表时间:
2019-05
影响因子:
13.8
通讯作者:
Lacouture ME
Lacouture ME
中科院分区:
医学1区
文献类型:
--
作者:
Freites-Martinez A;Shapiro J;Goldfarb S;Nangia J;Jimenez JJ;Paus R;Lacouture ME

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细胞毒性化学疗法、分子靶向疗法、免疫疗法、放射疗法、干细胞移植和内分泌疗法可能导致毛发疾病(包括脱发、多毛症、增生、色素沉着和质地毛发变化)。这些变化背后的机制是多种多样的,仍然不完全清楚,阻碍了预防或治疗指南的制定。化疗诱导的脱发的心理社会影响主要在肿瘤学文献中得到了充分的记录,但是其他改变(如辐射诱导的脱发、多毛症、头发颜色或质地变化)对生活质量的影响尚未得到描述。本文综述了临床上显着的治疗相关的毛发疾病的癌症患者,潜在的病理生理机制,严重程度分级量表,患者报告的生活质量的工具,管理策略,和未来的转化研究的机会。
Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders (including alopecia, hirsutism, hypertrichosis, pigmentary and textural hair changes). The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy -induced alopecia has been well-documented mainly in the oncology literature, however the effect of other alterations such as radiation-induced alopecia, hirsutism, changes in hair color or texture on quality of life have not been described. This article reviews clinically significant therapy-related hair disorders in cancer patients, underlying pathophysiological mechanisms, severity grading scales, patient reported quality of life instruments, management strategies, and future translational research opportunities.
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