Chemical constituents, clinical efficacy and molecular mechanisms of the ethanol extract of Abelmoschus manihot flowers in treatment of kidney diseases.
Chemical constituents, clinical efficacy and molecular mechanisms of the ethanol extract of Abelmoschus manihot flowers in treatment of kidney diseases.
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DOI：
10.1002/ptr.6818
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Gu HF
中科院分区：
文献类型：
--
作者：
Li N;Tang H;Wu L;Ge H;Wang Y;Yu H;Zhang X;Ma J;Gu HF
麻葵，又称黄葵，是锦葵科一年生开花草本植物。黄葵花的乙醇提取物是一种中药，已被制成黄葵胶囊，用于肾脏疾病患者的治疗。对慢性肾病、糖尿病肾病、IgA肾病患者的临床症状疗效主要是改善肾功能、减少蛋白尿。黄葵胶囊治疗肾脏疾病的机制可能包括减轻炎症和抗氧化应激，提高免疫应答，保护肾小管上皮细胞，改善足细胞凋亡，改善肾小球硬化和系膜增殖，抑制肾纤维化。本文首先介绍了白桦花乙醇提取物的化学成分和药动学特征。我们总结了肾脏疾病的临床和流行病学相关性，特别是在中国大陆，并讨论了黄葵胶囊治疗肾脏疾病可能的分子机制。最后，对该中药在肾脏疾病中的细胞分子机制及应用研究进行了展望。
Abelmoschus manihot, also called as “Huangkui” in Chinese, is an annual flowering herb plant in the family of Malvaceae. As a traditional Chinese medicine, the ethanol extract of the flower in Abelmoschus manihot is made as Huangkui capsule and has been used for medication of the patients with kidney diseases. Its efficacy in clinical symptoms is mainly improving renal function and reducing proteinuria among the patients with chronic kidney disease, diabetic kidney disease or IgA nephropathy. The possible mechanism of Huangkui capsule treatment in kidney diseases may include reducing inflammation and anti‐oxidative stress, improving immune response, protecting renal tubular epithelial cells, ameliorating podocyte apoptosis, glomerulosclerosis and mesangial proliferation, as well as inhibiting renal fibrosis. In this review, we first described chemical constituents and pharmacokinetic characteristics in ethanol extract of the flower of Abelmoschus manihot. We then summarized the clinical and epidemiological relevancies of kidney diseases particularly in the mainland of China and discussed the possible molecular mechanisms of Huangkui capsule in the treatment of kidney diseases. Finally, we prospected further research on cellular and molecular mechanisms and application of this Chinese natural medicine in kidney diseases.
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DOI：
10.2147/dmso.s195456
发表时间：
2019-01-01
期刊：
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
影响因子：
--
作者：
Jiang, Xiyuan;Yu, Jiangyi;Li, Nan
通讯作者：
Li, Nan
黄蜀葵总黄酮通过抑制 iRhom2/TACE 信号通路活性改善大鼠糖尿病肾病
影响因子：
3.8
作者：
Liu S;Ye L;Tao J;Ge C;Huang L;Yu J
通讯作者：
Yu J
影响因子：
2.5
作者：
Li P;Chen YZ;Lin HL;Ni ZH;Zhan YL;Wang R;Yang HT;Fang JA;Wang NS;Li WG;Sun XF;Chen XM
通讯作者：
Chen XM
影响因子：
3.2
作者：
Chen J
通讯作者：
Chen J
影响因子：
0.7
作者：
Ferenbach DA;Bonventre JV
通讯作者：
Bonventre JV