Intellectual impairment in school-age children exposed to manganese from drinking water.
Intellectual impairment in school-age children exposed to manganese from drinking water.
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DOI：
10.1289/ehp.1002321
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发表时间：
2011-01
影响因子：
10.4
通讯作者：
Mergler D
中科院分区：
文献类型：
--
作者：
Bouchard MF;Sauvé S;Barbeau B;Legrand M;Brodeur MÈ;Bouffard T;Limoges E;Bellinger DC;Mergler D
锰是一种必需的营养物质，但过量的锰可能是一种强有力的神经毒物。尽管锰在地下水中普遍存在，但与这种暴露源有关的风险在很大程度上是未知的。我们的第一个目的是评估从饮用水中接触锰与儿童智商（IQ）之间的关系。其次，我们研究了从饮水和饮食中摄取的锰与儿童头发锰浓度之间的关系。这项横断面研究包括362名生活在地下水供应社区的6-13岁儿童。测定了家庭自来水（MnW）和儿童头发（MnH）中锰的浓度。我们使用食物频率问卷来估计从饮水和饮食中摄入的锰，并使用韦氏简化智力量表评估智商。儿童家庭自来水MnW中位数为34 μg/L（范围1 ~ 2700 μg/L）。MnH随水锰摄入量的增加而增加，但不随膳食锰摄入量的增加而增加。较高的MnW和MnH与较低的智商得分显著相关。在调整了母亲智力、家庭收入和其他潜在混杂因素后，MnW增加10倍与智商下降2.4点相关（95%置信区间：- 3.9至- 0.9;p < 0.01）。在MnW最低和最高的五分位数的孩子之间，智商有6.2分的差异。MnW与绩效智商的关系比与言语智商的关系更强。这项横断面研究的结果表明，暴露于地下水中常见水平的锰与儿童智力损伤有关。
Manganese is an essential nutrient, but in excess it can be a potent neurotoxicant. Despite the common occurrence of manganese in groundwater, the risks associated with this source of exposure are largely unknown. Our first aim was to assess the relations between exposure to manganese from drinking water and children’s intelligence quotient (IQ). Second, we examined the relations between manganese exposures from water consumption and from the diet with children’s hair manganese concentration. This cross-sectional study included 362 children 6–13 years of age living in communities supplied by groundwater. Manganese concentration was measured in home tap water (MnW) and children’s hair (MnH). We estimated manganese intake from water ingestion and the diet using a food frequency questionnaire and assessed IQ with the Wechsler Abbreviated Scale of Intelligence. The median MnW in children’s home tap water was 34 μg/L (range, 1–2,700 μg/L). MnH increased with manganese intake from water consumption, but not with dietary manganese intake. Higher MnW and MnH were significantly associated with lower IQ scores. A 10-fold increase in MnW was associated with a decrease of 2.4 IQ points (95% confidence interval: −3.9 to −0.9; p < 0.01), adjusting for maternal intelligence, family income, and other potential confounders. There was a 6.2-point difference in IQ between children in the lowest and highest MnW quintiles. MnW was more strongly associated with Performance IQ than Verbal IQ. The findings of this cross-sectional study suggest that exposure to manganese at levels common in groundwater is associated with intellectual impairment in children.
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影响因子：
3.4
作者：
Chang, Yongmin;Kim, Yangho;Jeong, Kyoung Sook
通讯作者：
Jeong, Kyoung Sook
影响因子：
3.5
作者：
Bellinger, David C.
通讯作者：
Bellinger, David C.
DOI：
10.1196/annals.1306.009
发表时间：
2004-01-01
期刊：
REDOX-ACTIVE METALS IN NEUROLOGICAL DISORDERS
影响因子：
--
作者：
Dobson, AW;Erikson, KM;Aschner, M
通讯作者：
Aschner, M
影响因子：
4.7
作者：
Guilarte, Tomas R.;Burton, Neal C.;Schneider, Jay S.
通讯作者：
Schneider, Jay S.
影响因子：
6.1
作者：
ERIKSSON, H;MAGISTE, K;HEILBRONN, E
通讯作者：
HEILBRONN, E