New Therapeutic Horizon of Graves' Hyperthyroidism: Treatment Regimens Based on Immunology and Ingredients From Traditional Chinese Medicine.
New Therapeutic Horizon of Graves' Hyperthyroidism: Treatment Regimens Based on Immunology and Ingredients From Traditional Chinese Medicine.
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DOI：
10.3389/fphar.2022.862831
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发表时间：
2022
影响因子：
5.6
通讯作者：
Lu, Fuer
中科院分区：
文献类型：
--
作者：
He, Qiongyao;Dong, Hui;Gong, Minmin;Guo, Yujin;Xia, Qingsong;Gong, Jing;Lu, Fuer
关键词：
Graves病是一种以甲状腺肿大和甲状腺功能亢进为特征的自身免疫性疾病，25%的患者会发展为GO。传统的治疗选择，如抗甲状腺药物、放射性碘或甲状腺切除术，在过去70年中基本上没有变化。对于许多患者，抗甲状腺药物治疗后复发率高，消融术和甲状腺切除术后终身甲状腺功能减退。部分患者的症状和生活质量未得到有效改善。对新治疗方案的临床需求，加上对Graves病病理生理学和免疫生物学的更深入了解，导致了几种新的治疗理念的出现，包括生物制剂，小分子肽，免疫调节剂和teprotumumab，一种靶向IGF-1 R的特异性抗体。此外，中医元素也引起了现代医学越来越多的关注，一些有效成分已成功用于治疗自身免疫性疾病。本文从Graves'甲亢的病理生理和临床治疗效果出发，综述了近年来Graves'甲亢治疗的新策略，总结了中药治疗Graves'甲亢的有效成分，并探讨了其作用机制。这些疗法为Graves病的治疗打开了一扇新的窗口，但确切的机制和研究方向仍需进一步探讨。
Graves’ disease is an autoimmune disease characterized by goiter and hyperthyroidism, and 25% patients develop GO. Traditional treatment options, such as antithyroid drugs, radioiodine or thyroidectomy, have remained largely unchanged over the past 70 years. For many patients, there is a high rate of recurrence after antithyroid drugs and lifelong hypothyroidism after ablation and thyroidectomy. The symptoms and quality of life of some patients have not been effectively improved. The clinical demand for new therapeutic regimens, coupled with a deeper understanding of the pathophysiology and immunobiology of Graves’ disease, has led to the emergence of several new therapeutic ideas, including biologics, small molecule peptides, immunomodulators and teprotumumab, a specific antibody targeting IGF-1R. Besides, the elements of TCM have attracted more and more interests in modern medicine, because some effective components have been successfully used in the treatment of autoimmune diseases. Based on the pathophysiology and efficacy of clinical management and treatment in Graves’ hyperthyroidism, here we review the new strategies under investigation and summarize the effective components of traditional Chinese medicine used for Graves’ hyperthyroidism, and explore their mechanisms. These therapies have opened a new window for the treatment of Graves’ disease, but the exact mechanism and the research direction still need to be further explored.
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影响因子：
17.1
作者：
通讯作者：
--
影响因子：
5.8
作者：
HIROMATSU, Y;TANAKA, K;NONAKA, K
通讯作者：
NONAKA, K
DOI：
10.1073/pnas.172398899
发表时间：
2002-09-03
影响因子：
11.1
作者：
Dinkova-Kostova, AT;Holtzclaw, WD;Talalay, P
通讯作者：
Talalay, P
影响因子：
5.4
作者：
Diana, T.;Wuester, C.;Kahaly, G. J.
通讯作者：
Kahaly, G. J.
DOI：
10.4049/jimmunol.1200311
发表时间：
2012-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Huber AK;Finkelman FD;Li CW;Concepcion E;Smith E;Jacobson E;Latif R;Keddache M;Zhang W;Tomer Y
通讯作者：
Tomer Y