The gut microbiota and inflammatory bowel diseases.
The gut microbiota and inflammatory bowel diseases.
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DOI：
10.1016/j.trsl.2016.06.002
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Chang EB
中科院分区：
文献类型：
--
作者：
Miyoshi J;Chang EB
炎症性肠病 (IBD) 是一种病因不明的慢性疾病，影响着美国超过 100 万人和欧洲超过 250 万人。然而，它们也在全球范围内扩张，随着亚洲、南美洲和中东工业化程度的提高，它们影响到了这些地区的人口。这些疾病被认为是由遗传、环境和微生物因素共同引发的，这些因素触发了异常的免疫和组织反应，导致肠道炎症。独立于培养的研究、实验模型和生物信息学方法的进展提高了我们对肠道微生物群在 IBD 中作用的理解。然而，由于当前实验模型的局限性以及在人体研究中建立因果关系的困难，确定和理解IBD中肠道菌群失调和宿主-微生物群相互作用改变的功能后果仍然是一个挑战。需要不断开发新方法并改进临床研究设计，以更好地了解 IBD 中遗传、微生物和免疫因素的相互作用。这些知识可以应用于临床，以改善 IBD 的治疗策略和结果。
Inflammatory bowel diseases (IBD) are chronic diseases of unclear etiology that affect over 1 million individuals in the United States and over 2.5 million people in Europe. However, they are also expanding globally, affecting populations in Asia, South America, and the Middle East as they become more industrialized. These diseases are believed to arise from the convergence of genetic, environmental, and microbial factors that trigger aberrant immune and tissue responses, resulting in intestinal inflammation. Advances in cultivation-independent investigations, experimental models, and bioinformatics approaches have improved our understanding of the role of gut microbiota in IBD. However, determining and understanding the functional consequences of gut dysbiosis and altered host-microbiota interactions in IBD remain a challenge due to the limits of current experimental models and difficulty in establishing causal links in human-based investigations. Continued development of new methodologies and improvements in clinical study design are needed to better understand the interplay of genetic, microbial, and immunological factors in IBD. This knowledge can then be applied clinically to improve therapeutic strategies and outcomes for IBD.
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影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
6.7
作者：
Dreux N;Denizot J;Martinez-Medina M;Mellmann A;Billig M;Kisiela D;Chattopadhyay S;Sokurenko E;Neut C;Gower-Rousseau C;Colombel JF;Bonnet R;Darfeuille-Michaud A;Barnich N
通讯作者：
Barnich N
影响因子：
2.8
作者：
Attene-Ramos, Matias S.;Nava, Gerardo M.;Gaskins, H. Rex
通讯作者：
Gaskins, H. Rex
影响因子：
9.8
作者：
Angelberger, Sieglinde;Reinisch, Walter;Erry, David B.
通讯作者：
Erry, David B.