Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
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DOI：
10.1038/nature11225
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发表时间：
2012-07-05
期刊：
影响因子：
64.8
通讯作者：
Chang, Eugene B.
中科院分区：
文献类型：
--
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
在过去的世纪里，西方人群的复合人体微生物组可能发生了变化，这是由新的环境触发因素引起的，这些因素往往对人类健康产生负面影响。在这里，我们表明，高饱和（牛奶衍生）脂肪（MF），但不多不饱和（红花油）脂肪（PUFA）的饮食消费，改变了微生物聚集的条件，并促进了低丰度，亚硫酸盐还原的致病菌，Bilophila wadsophoria的扩张。这与促炎性TH 1免疫应答和遗传易感IL-10−/−小鼠结肠炎发病率增加有关，但与野生型小鼠无关。这些作用是由MF促进的肝胆汁酸的牛磺酸结合介导的，这增加了亚硫酸盐还原微生物（如B）使用的有机硫的可用性。wadsobiria。例如，当给小鼠喂食添加牛磺胆酸但不添加甘氨胆酸的低脂（LF）饮食时，出现大量B。在IL-10 −/−小鼠中观察到瓦氏症和结肠炎的发展。总之，这些数据表明，膳食脂肪，通过促进宿主胆汁酸组成的变化，可以显着改变肠道微生物聚集的条件，导致生态失调，可以扰乱免疫稳态。这些数据提供了一个合理的机制基础，通过这种机制，某些饱和脂肪含量高的西式饮食可能会增加遗传易感宿主中复杂免疫介导疾病（如炎症性肠病）的患病率。
The composite human microbiome of Western populations has likely changed over the past century, brought on by new environmental triggers that often have a negative impact on human health. Here we show that consumption of a diet high in saturated (milk derived)-fat (MF), but not polyunsaturated (safflower oil)-fat (PUFA), changes the conditions for microbial assemblage and promotes expansion of a low abundance, sulfite-reducing pathobiont, Bilophila wadsworthia. This was associated with a pro-inflammatory TH1 immune response and increased incidence of colitis in genetically susceptible IL-10−/−, but not wild type mice. These effects are mediated by MF-promoted taurine-conjugation of hepatic bile acids, which increases the availability of organic sulfur used by sulfite-reducing microbes like B. wadsworthia. When mice were fed a low-fat (LF) diet supplemented with taurocholic, but not with glycocholic acid, for example, a bloom of B. wadsworthia and development of colitis were observed in IL10−/− mice. Together these data show that dietary fats, by promoting changes in host bile acid composition, can dramatically alter conditions for gut microbial assemblage, resulting in dysbiosis that can perturb immune homeostasis. The data provide a plausible mechanistic basis by which Western type diets high in certain saturated fats might increase the prevalence of complex immune-mediated diseases like inflammatory bowel diseases in genetically susceptible hosts.
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影响因子：
3.6
作者：
Dussurget, O;Cabanes, D;Cossart, P
通讯作者：
Cossart, P
影响因子：
4.2
作者：
GIBSON, GR;CUMMINGS, JH;MACFARLANE, GT
通讯作者：
MACFARLANE, GT
DOI：
10.1128/cdli.9.6.1160-1164.2002
发表时间：
2002-11-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
Ananieva, O;Nilsson, I;Wadström, T
通讯作者：
Wadström, T
影响因子：
3
作者：
Rueda, A;Manas, M;MartinezVictoria, E
通讯作者：
MartinezVictoria, E
影响因子：
4.2
作者：
Scanlan, Pauline D.;Shanahan, Fergus;Marchesi, Julian R.
通讯作者：
Marchesi, Julian R.