Resting state networks and consciousness: alterations of multiple resting state network connectivity in physiological, pharmacological, and pathological consciousness States.
Resting state networks and consciousness: alterations of multiple resting state network connectivity in physiological, pharmacological, and pathological consciousness States.
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DOI：
10.3389/fpsyg.2012.00295
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发表时间：
2012
影响因子：
3.8
通讯作者：
Demertzi A
中科院分区：
文献类型：
--
作者：
Heine L;Soddu A;Gómez F;Vanhaudenhuyse A;Tshibanda L;Thonnard M;Charland-Verville V;Kirsch M;Laureys S;Demertzi A
为了更好地了解静息状态活动对意识认知的功能贡献，我们旨在回顾生理（睡眠），药理学（麻醉）和病理性意识改变状态（如脑死亡，昏迷，植物人状态/无反应觉醒综合征和最低意识状态）下功能磁共振成像（fMRI）功能连接的增加和减少。被审查的静息状态网络的DMN，左，右执行控制，显着性，感觉，听觉和视觉网络。我们强调了一些方法学问题，主要是在假设驱动的种子相关分析和数据驱动的独立成分分析方法在严重受伤的大脑的静息状态分析。最后，我们试图将我们的讨论置于意识过程的理论框架中。我们认为，这种“损伤”方法使我们能够更好地确定正常意识认知发生的必要条件。在临床层面，我们承认静息状态范式的技术优势。事实上，快速和容易的采集比临床人群中的激活范例更可取。最后，我们强调需要验证的诊断和预后价值的功能磁共振成像静息状态测量在非交通性脑损伤患者。
In order to better understand the functional contribution of resting state activity to conscious cognition, we aimed to review increases and decreases in functional magnetic resonance imaging (fMRI) functional connectivity under physiological (sleep), pharmacological (anesthesia), and pathological altered states of consciousness, such as brain death, coma, vegetative state/unresponsive wakefulness syndrome, and minimally conscious state. The reviewed resting state networks were the DMN, left and right executive control, salience, sensorimotor, auditory, and visual networks. We highlight some methodological issues concerning resting state analyses in severely injured brains mainly in terms of hypothesis-driven seed-based correlation analysis and data-driven independent components analysis approaches. Finally, we attempt to contextualize our discussion within theoretical frameworks of conscious processes. We think that this “lesion” approach allows us to better determine the necessary conditions under which normal conscious cognition takes place. At the clinical level, we acknowledge the technical merits of the resting state paradigm. Indeed, fast and easy acquisitions are preferable to activation paradigms in clinical populations. Finally, we emphasize the need to validate the diagnostic and prognostic value of fMRI resting state measurements in non-communicating brain damaged patients.
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
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影响因子：
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影响因子：
5.7
作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.0601417103
发表时间：
2006-09-12
影响因子：
11.1
作者：
Damoiseaux, J. S.;Rombouts, S. A. R. B.;Beckmann, C. F.
通讯作者：
Beckmann, C. F.