Translating RDoC to Real-World Impact in Developmental Psychopathology: A Neurodevelopmental Framework for Application of Mental Health Risk Calculators.
Translating RDoC to Real-World Impact in Developmental Psychopathology: A Neurodevelopmental Framework for Application of Mental Health Risk Calculators.
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DOI：
10.1017/s0954579421000651
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发表时间：
2021-12
影响因子：
3.3
通讯作者：
Wakschlag LS
中科院分区：
文献类型：
--
作者：
MacNeill LA;Allen NB;Poleon RB;Vargas T;Osborne KJ;Damme KSF;Barch DM;Krogh-Jespersen S;Nielsen AN;Norton ES;Smyser CD;Rogers CE;Luby JL;Mittal VA;Wakschlag LS
美国国家精神卫生研究所的研究领域标准（RDoC）已经促使一种范式的转变，从分类精神障碍，以考虑多层次的脆弱性的概率风险的障碍。然而，缺乏基于神经发育的临床决策工具限制了RDoC的现实影响。结合发展精神病理学原理和统计方法，实现了RDoC的临床实施，以告知神经发育风险。在这篇概念性论文中，我们介绍了概率心理健康风险计算器作为这种翻译的创新，并制定了一个研究议程，用于生成一个RDoC-和发展知情的范式，可用于预测从幼儿到青年的一系列发展性精神病理学。我们讨论的方法，权衡增量效用预测的基础上的强度和负担的评估，增加发展变化模式，评估结果的考虑因素，和综合数据的方法。在整个过程中，我们说明了不同的神经发育途径和表型的风险计算器的方法。最后，我们讨论了现实世界中实施这些方法，以提高早期识别和预防发展性精神病理学。我们建议心理健康风险计算器可以在RDoC的多个分析单元和发展科学之间建立一个必要的桥梁。
The National Institute of Mental Health Research Domain Criteria’s (RDoC) has prompted a paradigm shift from categorical psychiatric disorders to considering multiple levels of vulnerability for probabilistic risk of disorder. However, the lack of neurodevelopmentally-based tools for clinical decision-making has limited RDoC’s real-world impact. Integration with developmental psychopathology principles and statistical methods actualize the clinical implementation of RDoC to inform neurodevelopmental risk. In this conceptual paper, we introduce the probabilistic mental health risk calculator as an innovation for such translation and lay out a research agenda for generating an RDoC- and developmentally-informed paradigm that could be applied to predict a range of developmental psychopathologies from early childhood to young adulthood. We discuss methods that weigh the incremental utility for prediction based on intensity and burden of assessment, the addition of developmental change patterns, considerations for assessing outcomes, and integrative data approaches. Throughout, we illustrate the risk calculator approach with different neurodevelopmental pathways and phenotypes. Finally, we discuss real-world implementation of these methods for improving early identification and prevention of developmental psychopathology. We propose that mental health risk calculators can build a needed bridge between RDoC’s multiple units of analysis and developmental science.
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影响因子：
7
作者：
Curran, Patrick J.;Hussong, Andrea M.
通讯作者：
Hussong, Andrea M.
影响因子：
3.8
作者：
Boker, SM;Nesselroade, JR
通讯作者：
Nesselroade, JR
影响因子：
120.7
作者：
Allen, Norrina B.;Siddique, Juned;Wilkins, John T.;Shay, Christina;Lewis, Cora E.;Goff, David C.;Jacobs, David R., Jr.;Liu, Kiang;Lloyd-Jones, Donald
通讯作者：
Lloyd-Jones, Donald
DOI：
10.1126/science.1248429
发表时间：
2014-03-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Campbell F;Conti G;Heckman JJ;Moon SH;Pinto R;Pungello E;Pan Y
通讯作者：
Pan Y
DOI：
10.1080/15374416.2015.1038827
发表时间：
2015-09-03
影响因子：
4.2
作者：
Beauchaine, Theodore P.
通讯作者：
Beauchaine, Theodore P.