Immune regulation in the retina.
Immune regulation in the retina.
复制标题
视网膜中的免疫调节。
DOI：
10.1007/s12026-009-8146-1
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发表时间：
2010-07
影响因子：
4.4
通讯作者：
Hooks JJ
中科院分区：
文献类型：
--
作者：
Detrick B;Hooks JJ
视网膜的免疫反应在炎症和感染中至关重要，但对这种反应的调节是必不可少的。视网膜色素上皮细胞（RPE）是一种独特的视网膜细胞，具有支持视网膜健康的许多基本功能。在这篇综述中，我们强调RPE细胞如何在免疫防御中发挥关键作用。由于RPE细胞表达tlr、补体成分、MHC I类和II类分子，并作为抗原呈递细胞，因此它协调先天免疫和适应性免疫。此外，这两种免疫反应都导致产生过多的细胞因子，主要是促炎。为了抵消这些炎症因子和沉默不想要的免疫反应，RPE细胞也产生抑制分子。最近，慢性免疫反应性与许多视网膜疾病有关，如年龄相关性黄斑变性（AMD）。目前的证据表明，过度视网膜炎症的产生可能是RPE免疫抑制因子丧失的结果。在此，我们总结了RPE细胞与免疫反应的各种相互作用，并强调了RPE细胞如何在这种动态环境中生存和参与。
Immune reactivity in the retina can be critically important in inflammation and infections, but regulation of this response is essential. The retinal pigment epithelial (RPE), a unique retinal cell, displays a number of essential functions to support the health of the retina. In this review, we highlight how the RPE cell plays a pivotal role in immune defense. The RPE cell orchestrates both innate and adaptive immunity since it expresses TLRs, complement components, MHC class I and II molecules, and serves as an antigen presenting cell. Moreover, both of these immune responses result in the production of a plethora of cytokines, mainly proinflammatory. In order to counteract these inflammatory factors and silence unwanted immune reactivity, the RPE cell also generates suppressive molecules. Recently, chronic immune reactivity has been implicated in a number of retinal diseases, such as age-related macular degeneration (AMD). Current evidence suggests that the generation of excessive retinal inflammation may be the consequence of a loss of RPE immunosuppressive factors. Herein, we summarize the varied interactions of the RPE cell with the immune response and highlight how the RPE cell survives and participates in this dynamic environment.
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影响因子：
4.4
作者：
Hooks, JJ;Wang, Y;Detrick, B
通讯作者：
Detrick, B
影响因子：
4.4
作者：
Edwards, Albert O.;Chen, Dequan;Tosakulwong, Nirubol
通讯作者：
Tosakulwong, Nirubol
影响因子：
12.8
作者：
Chin, Marian S.;Caruso, Rafael C.;Hooks, John J.
通讯作者：
Hooks, John J.
影响因子：
4.4
作者：
Cho Y;Wang JJ;Chew EY;Ferris FL 3rd;Mitchell P;Chan CC;Tuo J
通讯作者：
Tuo J
影响因子：
3.7
作者：
Komurasaki, Y;Nagineni, CN;Hooks, JJ
通讯作者：
Hooks, JJ