Differences in functional connectivity between alcohol dependence and internet gaming disorder.
Differences in functional connectivity between alcohol dependence and internet gaming disorder.
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DOI：
10.1016/j.addbeh.2014.09.006
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发表时间：
2015-03
影响因子：
4.4
通讯作者：
Renshaw PF
中科院分区：
文献类型：
--
作者：
Han JW;Han DH;Bolo N;Kim B;Kim BN;Renshaw PF
据报道，网络游戏障碍（IGD）和酒精依赖（AD）具有共同的临床特征，包括渴望和过度参与，尽管会产生负面后果。然而，IGD 患者和 AD 患者在化学中毒、患病年龄以及视觉和听觉刺激方面也存在不同的临床因素。我们评估了 15 名 IGD 患者和 16 名 AD 患者的前额叶、纹状体和颞叶内的大脑功能连接。对 IGD 和 AD 患者的抑郁、焦虑和注意力缺陷多动障碍症状进行了评估。 AD 和 IGD 受试者的背外侧前额叶皮层 (DLPFC)、扣带皮层和小脑之间均具有正功能连接。此外，两组人的 DLPFC 和眶额皮层之间都具有负功能连接。然而，AD 受试者的 DLPFC、颞叶和纹状体区之间具有正功能连接，而 IGD 受试者的 DLPFC、颞叶和纹状体区之间具有负功能连接。 AD 和 IGD 受试者可能存在执行功能缺陷，包括自我控制和适应性反应问题。然而，IGD 受试者 DLPFC 和纹状体区之间的负连接与 AD 受试者中观察到的连接不同，可能是由于患病年龄较早、不同的合并症以及视觉和听觉刺激所致。
Internet gaming disorder (IGD) and alcohol dependence (AD) have been reported to share clinical characteristics including craving and over-engagement despite negative consequences. However, there are also clinical factors that differ between individuals with IGD and those with AD in terms of chemical intoxication, prevalence age, and visual and auditory stimulation. We assessed brain functional connectivity within the prefrontal, striatum, and temporal lobe in 15 patients with IGD and in 16 patients with AD. Symptoms of depression, anxiety, and the attention deficit hyperactivity disorder were assessed in patients with IGD and in patients with AD. Both AD and IGD subjects have positive functional connectivity between the dorsolateral prefrontal cortex (DLPFC), cingulate, and cerebellum. In addition, both groups have negative functional connectivity between the DLPFC and the orbitofrontal cortex. However, the AD subjects have positive functional connectivity between the DLPFC, temporal lobe and striatal areas while IGD subjects have negative functional connectivity between the DLPFC, temporal lobe and striatal areas. AD and IGD subjects may share deficits in executive function, including problems with self-control and adaptive responding. However, the negative connectivity between the DLPFC and the striatal areas in IGD subjects, different from the connectivity observed in AD subjects, may be due to the earlier prevalence age, different comorbid diseases as well as visual and auditory stimulation.
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DOI：
10.3109/00952990.2010.491884
发表时间：
2010-09
期刊：
The American journal of drug and alcohol abuse
影响因子：
--
作者：
Grant JE;Potenza MN;Weinstein A;Gorelick DA
通讯作者：
Gorelick DA
影响因子：
4.4
作者：
Fox, H. C.;Hong, K. A.;Sinha, R.
通讯作者：
Sinha, R.
影响因子：
3.7
作者：
DellaCroce, John T.;Vitale, Albert T.
通讯作者：
Vitale, Albert T.
网络游戏成瘾者静息态大脑活动区域同质性的变化
DOI：
10.1186/1744-9081-8-41
发表时间：
2012-08-18
期刊：
Behavioral and brain functions : BBF
影响因子：
--
作者：
Dong G;Huang J;Du X
通讯作者：
Du X
DOI：
10.1089/109493101300210286
发表时间：
2001-06-01
期刊：
CYBERPSYCHOLOGY & BEHAVIOR
影响因子：
--
作者：
Beard, KW;Wolf, EM
通讯作者：
Wolf, EM