The IMGT/HLA database.

The IMGT/HLA database.
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DOI:
10.1093/nar/gks949
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发表时间:
2013-01
影响因子:
14.9
通讯作者:
Marsh SG
Marsh SG
中科院分区:
生物学2区
文献类型:
--
作者:
Robinson J;Halliwell JA;McWilliam H;Lopez R;Parham P;Marsh SG

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自IMGT/HLA数据库首次发布以来,已经有14年了,它为HLA社区提供了一个可搜索的高度管理的HLA序列存储库。HLA复合物位于人类6号染色体6p21.3区域,包含220多个不同功能的基因。在这些基因中,有21个基因编码免疫系统中高度多态性的蛋白质。这些HLA基因和等位基因的命名及其质量控制由世界卫生组织HLA系统因子命名委员会负责。通过HLA信息学小组的工作,并与欧洲生物信息学研究所合作,我们能够通过网站http://www.ebi.ac.uk/imgt/hla/向公众提供这些数据。定期更新网站,确保新的和确认的序列被分散到HLA社区和更广泛的研究和临床社区。本文描述了添加到IMGT/HLA项目中的最新更新和其他工具。
It is 14 years since the IMGT/HLA database was first released, providing the HLA community with a searchable repository of highly curated HLA sequences. The HLA complex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of diverse function. Of these, 21 genes encode proteins of the immune system that are highly polymorphic. The naming of these HLA genes and alleles and their quality control is the responsibility of the World Health Organization Nomenclature Committee for Factors of the HLA System. Through the work of the HLA Informatics Group and in collaboration with the European Bioinformatics Institute, we are able to provide public access to these data through the website http://www.ebi.ac.uk/imgt/hla/. Regular updates to the website ensure that new and confirmatory sequences are dispersed to the HLA community and the wider research and clinical communities. This article describes the latest updates and additional tools added to the IMGT/HLA project.
DOI: 10.1093/nar/gkq313
发表时间: 2010-07
影响因子: 14.9
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