Flavonoids Regulate Inflammation and Oxidative Stress in Cancer.

Flavonoids Regulate Inflammation and Oxidative Stress in Cancer.
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类黄酮调节癌症中的炎症和氧化应激

DOI:
10.3390/molecules25235628
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发表时间:
2020-11-30
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
Zhang L
Zhang L
中科院分区:
其他
文献类型:
--
作者:
Li G;Ding K;Qiao Y;Zhang L;Zheng L;Pan T;Zhang L

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癌症是全球第二大死亡原因。每年有数百万人死于癌症。在过去的二十年里,天然黄酮类化合物的抗癌作用已成为许多实验室的热门话题。与此同时,类黄酮,其中超过8000分子是已知的日期,是潜在的候选人,为抗癌药物的发现。本文综述了近年来基于数据库和临床研究的黄酮类化合物的主要抗癌作用,并探讨了其通过炎症和氧化应激作用的潜在抗癌机制。结果表明,黄酮类化合物可通过NF-κB等抗炎机制调节肿瘤的炎症反应和氧化应激,从而实现抗肿瘤作用。
Cancer is the second leading cause of death globally. Millions of persons die due to cancer each year. In the last two decades, the anticancer effects of natural flavonoids have become a hot topic in many laboratories. Meanwhile, flavonoids, of which over 8000 molecules are known to date, are potential candidates for the discovery of anticancer drugs. The current review summarizes the major flavonoid classes of anticancer efficacy and discusses the potential anti-cancer mechanisms through inflammation and oxidative stress action, which were based on database and clinical studies within the past years. The results showed that flavonoids could regulate the inflammatory response and oxidative stress of tumor through some anti-inflammatory mechanisms such as NF-κB, so as to realize the anti-tumor effect.
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