The Effects of Flavonoids in Cardiovascular Diseases.
The Effects of Flavonoids in Cardiovascular Diseases.
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DOI：
10.3390/molecules25184320
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发表时间：
2020-09-21
期刊：
影响因子：
--
通讯作者：
Dogaru G
中科院分区：
文献类型：
--
作者：
Ciumărnean L;Milaciu MV;Runcan O;Vesa ȘC;Răchișan AL;Negrean V;Perné MG;Donca VI;Alexescu TG;Para I;Dogaru G
黄酮类化合物是植物和真菌的代谢产物。在观察到它们对心血管系统的有益作用后，近年来对黄酮类化合物的研究受到了特别的关注。黄酮类化合物发挥这些有利的作用主要是由于它们的抗氧化特性，这是由于能够减少低密度脂蛋白的氧化，从而改善脂质分布。对心血管系统的另一个积极作用是类黄酮产生血管舒张和调节内皮细胞凋亡过程的能力。研究人员认为，这些作用，包括它们的抗炎功能，是黄酮类化合物有效的抗氧化特性的结果，但最近的研究表明，与它们相关的多种信号通路，从而表明黄酮类化合物对人体的有益作用涉及更多机制。本综述旨在介绍这些物质的分类、它们在人体内的主要作用机制以及对心血管系统生理和病理状态的有益影响的最新数据。
Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation of their beneficial effects on the cardiovascular system. These favorable effects are exerted by flavonoids mainly due to their antioxidant properties, which result from the ability to decrease the oxidation of low-density lipoproteins, thus improving the lipid profiles. The other positive effect exerted on the cardiovascular system is the ability of flavonoids to produce vasodilation and regulate the apoptotic processes in the endothelium. Researchers suggested that these effects, including their anti-inflammatory function, are consequences of flavonoids’ potent antioxidant properties, but recent studies have shown multiple signaling pathways linked to them, thus suggesting that there are more mechanisms involved in the beneficial effect of the flavonoids on the human body. This review aims to present the latest data on the classification of these substances, their main mechanisms of action in the human body, and the beneficial effects on the physiological and pathological status of the cardiovascular system.
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影响因子：
7.1
作者：
Ellinger, Sabine;Reusch, Andreas;Helfrich, Hans-Peter
通讯作者：
Helfrich, Hans-Peter
影响因子：
6.1
作者：
Chuankhayan, Phimonphan;Rimlumduan, Thipwarin;Cairns, James R. Ketudat
通讯作者：
Cairns, James R. Ketudat
影响因子：
15.3
作者：
Carvalho Costa, D.;Costa, H. S.;Sanches-Silva, A.
通讯作者：
Sanches-Silva, A.
影响因子：
37.8
作者：
Cassidy A;Mukamal KJ;Liu L;Franz M;Eliassen AH;Rimm EB
通讯作者：
Rimm EB
影响因子：
6.1
作者：
Arts, ICW;van de Putte, B;Hollman, PCH
通讯作者：
Hollman, PCH