Differences in mortality of cancer patients with COVID-19 in a Brazilian cancer center.
Differences in mortality of cancer patients with COVID-19 in a Brazilian cancer center.
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DOI：
10.1053/j.seminoncol.2021.01.003
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发表时间：
2021-04
影响因子：
4
通讯作者：
Curado MP
中科院分区：
文献类型：
--
作者：
Fernandes GA;Feriani D;França E Silva ILA;Mendonça E Silva DR;Arantes PE;Canteras JDS;da Silva RR;Curado MP
分析巴西某癌症中心大流行期间癌症患者的COVID-19死亡率及相关因素，如年龄、性别、保险类型、COVID-19诊断情况和癌症组织学。横断面研究于2020年4月2日至2020年8月31日在巴西圣保罗的A.C. Camargo癌症中心（ACCCC）进行。病例摘自医院癌症登记处。按组织学计算COVID-19致死率；采用多元logistic回归确定与COVID-19死亡率相关的因素。采用log-rank检验比较各变量的生存曲线。在分析的411例患者中，51例（12.4%）死于COVID-19。死亡的平均年龄为63岁。肺癌（0.333）和血液癌（0.213）的死亡率更高，且与60岁以上的年龄相关。COVID-19死亡的最大机会是肺部（优势比，OR, 4.05, 95%可信区间，CI 1.33-12.34）和血液学（OR, 2.17, 95% CI 0.96-4.90）癌症病例，以及目前正在接受癌症治疗的患者（OR, 2.77, 95% CI 1.25-6.13）。在性别、年龄组、保险类型、COVID-19诊断情况和COVID-19癌症组织学方面，生存率无统计学差异。COVID-19在癌症患者中的死亡率是不均匀的。这些发现表明，需要采取个性化策略来管理不同类型的癌症，以降低COVID-19的死亡风险。
To analyze COVID-19 mortality in cancer patients and associated factors such as age, sex, type of insurance, situation at COVID-19 diagnosis, and cancer histology during the pandemic at a cancer center in Brazil. Cross-sectional study carried out from April 02, 2020 to August 31, 2020 at A.C. Camargo Cancer Center (ACCCC), in São Paulo, Brazil. Cases were extracted from the Hospital Cancer Registry. COVID-19 lethality rates by histology were calculated; multiple logistic regression was used to identify factors associated with COVID-19 mortality. The log-rank test was applied to compare the survival curves for each variable. Of the 411 patients analyzed, 51 (12.4%) died due to COVID-19. Death occurred at an average age of 63 years. The fatality rate was higher for lung (0.333) and hematological (0.213) cancers and was associated with age over 60 years. The greatest chances of death from COVID-19 were in cases of lung (odds ratio, OR, 4.05, 95% confidence interval, CI 1.33–12.34) and hematological (OR 2.17, 95% CI 0.96–4.90) cancers, and in patients currently undergoing cancer treatment (OR 2.77, 95% CI 1.25–6.13). There were no statistical differences in survival by sex, age group, type of insurance, situation at the diagnosis of COVID-19, and histology of cancer for COVID-19. Mortality due to COVID-19 in cancer patients is heterogeneous. These findings reinforce the need for individualized strategies for the management of different types of cancer that reduce the risk of death from COVID-19.
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影响因子：
8.4
作者：
Elkrief, Arielle;Desilets, Antoine;Routy, Bertrand
通讯作者：
Routy, Bertrand
影响因子：
51.1
作者：
Garassino, Marina Chiara;Whisenant, Jennifer G.;Horn, Leora
通讯作者：
Horn, Leora
影响因子：
28.2
作者：
Dai, Mengyuan;Liu, Dianbo;Cai, Hongbing
通讯作者：
Cai, Hongbing
影响因子：
51.1
作者：
Lee, Lennard Y. W.;Cozier, Jean-Baptiste;Kerr, Rachel
通讯作者：
Kerr, Rachel
影响因子：
45.3
作者：
Jee, Justin;Foote, Michael B.;Pessin, Melissa S.
通讯作者：
Pessin, Melissa S.