Neuro-Inflammation Modulation and Post-Traumatic Brain Injury Lesions: From Bench to Bed-Side.
Neuro-Inflammation Modulation and Post-Traumatic Brain Injury Lesions: From Bench to Bed-Side.
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DOI：
10.3390/ijms231911193
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发表时间：
2022-09-23
影响因子：
5.6
通讯作者：
Menon, David
中科院分区：
文献类型：
--
作者：
Jacquens, Alice;Needham, Edward J.;Zanier, Elisa R.;Degos, Vincent;Gressens, Pierre;Menon, David
头部创伤是年轻人残疾的最常见原因。它被称为一种无声的流行病，可以引起一系列症状，无论是神经系统（感觉运动缺陷），精神病（抑郁和焦虑症状）还是躯体疾病（眩晕，耳鸣，光幻视）。此外，儿童颅脑创伤（CT）在流行病学、发病机制和病理生理学方面存在一些特殊性，特别是与未成熟器官的攻击有关。与成年人一样，儿童的头部创伤可能产生终身影响，并可能导致社会和家庭孤立，学校困难，以及后来的社会职业逆境。改善对这些患者的院前和康复过程的管理可以降低继发性发病率和死亡率，但往往不能避免长期残疾。一个假设的贡献者，这一过程是慢性神经炎症，这可能伴随原发性病变，并促进其发展为三级病变。神经炎症是一个复杂的过程，涉及不同的因素，如神经胶质细胞（星形胶质细胞，小胶质细胞，少突胶质细胞），血脑屏障的渗透性，兴奋性毒性，氧衍生物的产生，细胞因子释放，组织损伤和神经元死亡。几项研究已经调查了各种治疗对体外以及动物和人类模型中创伤性脑损伤中神经炎症反应的影响。本综述的目的是检查已实施的各种抗炎治疗。
Head trauma is the most common cause of disability in young adults. Known as a silent epidemic, it can cause a mosaic of symptoms, whether neurological (sensory–motor deficits), psychiatric (depressive and anxiety symptoms), or somatic (vertigo, tinnitus, phosphenes). Furthermore, cranial trauma (CT) in children presents several particularities in terms of epidemiology, mechanism, and physiopathology—notably linked to the attack of an immature organ. As in adults, head trauma in children can have lifelong repercussions and can cause social and family isolation, difficulties at school, and, later, socio-professional adversity. Improving management of the pre-hospital and rehabilitation course of these patients reduces secondary morbidity and mortality, but often not without long-term disability. One hypothesized contributor to this process is chronic neuroinflammation, which could accompany primary lesions and facilitate their development into tertiary lesions. Neuroinflammation is a complex process involving different actors such as glial cells (astrocytes, microglia, oligodendrocytes), the permeability of the blood–brain barrier, excitotoxicity, production of oxygen derivatives, cytokine release, tissue damage, and neuronal death. Several studies have investigated the effect of various treatments on the neuroinflammatory response in traumatic brain injury in vitro and in animal and human models. The aim of this review is to examine the various anti-inflammatory therapies that have been implemented.
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影响因子：
4.5
作者：
Kumar PR;Essa MM;Al-Adawi S;Dradekh G;Memon MA;Akbar M;Manivasagam T
通讯作者：
Manivasagam T
影响因子：
1
作者：
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影响因子：
11.2
作者：
Arvin, KL;Han, BH;Holtzman, DM
通讯作者：
Holtzman, DM
影响因子：
8.3
作者：
Amin-Hanjani, S;Stagliano, NE;Moskowitz, MA
通讯作者：
Moskowitz, MA