Common variants in FKBP5 gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis.
Common variants in FKBP5 gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis.
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FKBP5 基因的常见变异与重度抑郁症 (MDD) 易感性：综合荟萃分析
DOI：
10.1038/srep32687
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发表时间：
2016-09-07
影响因子：
4.6
通讯作者：
Xu Q
中科院分区：
文献类型：
--
作者：
Rao S;Yao Y;Ryan J;Li T;Wang D;Zheng C;Xu Y;Xu Q
以前的研究调查了FKBP 5和MDD中常见变异之间的关联;然而，结果仍然不一致。为了对FKBP 5变异与MDD风险之间的关系进行全面的荟萃分析，共纳入了7项研究，涉及26582例受试者，包括12491例MDD患者和14091例对照。分析了4种常见的SNP（rs 1360780、rs 4713916、rs3800373和rs755658），这些SNP具有来自两项或多项研究的完整数据。在总样本中，使用随机效应模型，没有证据表明MDD与四种SNP中的任何一种之间存在显著关联。然而，在去除一项异质性德国研究后，如敏感性分析所示，rs 1360780 T等位基因（Z = 2.95，P = 0.003，OR = 1.06，95%CI = 1.02-1.11）和rs3800373 C等位基因（Z = 3.05，P = 0.002，OR = 1.07，95% CI 1.02-1.12）与MDD显著相关。因此，我们的研究为特定FKBP 5遗传变异与MDD风险之间的关联提供了支持。Rs 4713916与MDD无显著相关性;然而，该分析的统计功效有限，需要更大的样本量来进一步验证该结果。未来的研究还应调查FKBP 5和MDD之间可能存在的性别和种族特异性差异。
Previous studies have investigated the association between common variants in FKBP5 and MDD; however, the results remain inconsistent. In order to conduct a comprehensive meta-analysis of the association between FKBP5 variants and MDD risk, seven studies involving 26582 subjects, including 12491 cases with MDD and 14091 controls, were enrolled totally. Four common SNPs (rs1360780, rs4713916, rs3800373 and rs755658) with complete data from two or more studies were analyzed. In the total sample, there was no evidence of a significant association between MDD and any of the four SNPs using a random-effects model. However, after removing one heterogeneous German study, as indicated by sensitivity analysis, both the rs1360780 T-allele (Z = 2.95, P = 0.003, OR = 1.06, 95% CI = 1.02–1.11) and the rs3800373 C-allele (Z = 3.05, P = 0.002, OR = 1.07, 95% CI 1.02–1.12) were significantly associated with MDD in a fixed-effect model. Our study thus provides support for an association between specific FKBP5 genetic variants and MDD risk. Rs4713916 was not significantly associated with MDD; However, this analysis had limited statistical power and larger sample sizes are required to further validate this result. Future research should also investigate possible gender- and ethnicity-specific differences in the association between FKBP5 and MDD.
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影响因子：
11
作者：
Li, M.;Luo, X-j;Rietschel, M.;Lewis, C. M.;Mattheisen, M.;Mueller-Myhsok, B.;Jamain, S.;Leboyer, M.;Landen, M.;Thompson, P. M.;Cichon, S.;Noethen, M. M.;Schulze, T. G.;Sullivan, P. F.;Bergen, S. E.;Donohoe, G.;Morris, D. W.;Hargreaves, A.;Gill, M.;Corvin, A.;Hultman, C.;Toga, A. W.;Shi, L.;Lin, Q.;Shi, H.;Gan, L.;Meyer-Lindenberg, A.;Czamara, D.;Henry, C.;Etain, B.;Bis, J. C.;Ikram, M. A.;Fornage, M.;Debette, S.;Launer, L. J.;Seshadri, S.;Erk, S.;Walter, H.;Heinz, A.;Bellivier, F.;Stein, J. L.;Medland, S. E.;Vasquez, A. Arias;Hibar, D. P.;Franke, B.;Martin, N. G.;Wright, M. J.;Su, B.
通讯作者：
Su, B.
影响因子：
3.5
作者：
Kawamura, Yoshiya;Takahashi, Taiki;Sasak, Tsukasa
通讯作者：
Sasak, Tsukasa
影响因子：
30.8
作者：
Binder, EB;Salyakina, D;Muller-Myhsok, B
通讯作者：
Muller-Myhsok, B
影响因子：
11
作者：
通讯作者：
--
影响因子：
56.9
作者：
Murray, CJL;Lopez, AD
通讯作者：
Lopez, AD