Homologs of animal eyes absent (eya) genes are found in higher plants
Homologs of animal eyes absent (eya) genes are found in higher plants
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在高等植物中发现了动物眼睛缺失（eya）基因的同源物
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
M. Matsuoka
中科院分区：
文献类型：
--
作者：
Y. Takeda;S. Hatano;N. Sentoku;M. Matsuoka
动物眼缺失基因的同源物在器官发育的多个阶段起作用。它们在调节果蝇眼睛发育的遗传网络中的功能作用最近得到了广泛的分析。从水稻胚RNA cDNA文库中鉴定出eya的同源基因。相应的基因（OSEya1）编码一个保守的ED1结构域和一个短n端肽。OSEya1的ED1结构域与果蝇的产物具有25%的同源性和36%的相似性。哺乳动物和鱿鱼眼同源物与OSEya1的相似性约为35%。在苜蓿EST数据库和拟南芥基因组序列中也发现了同源序列（同源性53%，与OSEya1相似度65%）和同源性63%。因此，单子叶和双子叶中都存在同源物。ED1结构域的三个区域在动物和植物中都很保守。从核苷酸序列推断出的植物眼产物也含有短的n端肽。OSEya1基因位于6号染色体短臂上的wx基因和端粒之间。OSEya1在水稻胚、茎尖和颖果中表达。胚中的表达在胚发生过程中增加，直至授粉后7天，并优先定位于叶原基和茎尖分生组织。在花的分生组织中也有表达。讨论了OSEya1在高等植物中的功能，并将其与动物同源物进行了比较。OSEya1可能作为一个转录因子的亚基调控侧身器官的形态发生。
Abstract Homologs of the eyes absent (eya) gene in animals function at multiple stages in the development of organs. Their functional roles in the genetic network that regulates eye development in Drosophila have recently been extensively analyzed. A rice homolog of eya was identified from a cDNA library made from embryo RNA. The corresponding gene (OSEya1) encodes a conserved ED1 domain and a short N-terminal peptide. The ED1 domain of OSEya1 shows 25% identity and 36% similarity to the product of Drosophila eya. Mammalian and squid eya homologs show about 35% similarity to OSEya1. Homologous sequences were also found in the alfalfa EST database (53% identity and 65% similarity to OSEya1) and in the Arabidopsis genome sequence (63% identity). Therefore, eya homologs are present in both monocots and dicots. Three regions in the ED1 domain are well conserved in animals and plants. Plant eya products deduced from the nucleotide sequences also have short N-terminal peptides. The OSEya1 gene is located between the wx gene and the telomere on the short arm of chromosome 6. OSEya1 is expressed in the embryo, shoot apex, and caryopsis in rice. Expression in the embryo increases during embryogenesis until 7 days after pollination, with preferential localization in leaf primordia and the shoot apical meristem. Expression in the influorescence was observed in floral meristems. The functions of OSEya1 in higher plants are discussed and compared with those of their animal homologs. OSEya1 might regulate the morphogenesis of lateral organs as a subunit of a transcription factor.
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DOI：
10.1073/pnas.022626999
发表时间：
2002-02-19
影响因子：
11.1
作者：
Onuma, Y;Takahashi, S;Gehring, WJ
通讯作者：
Gehring, WJ
果蝇眼睛缺失基因的横传。
影响因子：
3.3
作者：
Leiserson,WM;Bonini,NM;Benzer,S
通讯作者：
Benzer,S
果蝇眼睛缺失基因在果蝇和脊椎动物之间保守的途径中指导异位眼睛的形成。
DOI：
10.1242/dev.124.23.4819
发表时间：
1997
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Bonini,NM;Bui,QT;Gray-Board,GL;Warrick,JM
通讯作者：
Warrick,JM
DOI：
10.1242/dev.124.1.45
发表时间：
1997
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Shen,W;Mardon,G
通讯作者：
Mardon,G
DOI：
10.1073/pnas.94.22.11974
发表时间：
1997-10-28
影响因子：
11.1
作者：
Xu, PX;Cheng, J;Maas, RL
通讯作者：
Maas, RL