Canceling actions involves a race between basal ganglia pathways.
Canceling actions involves a race between basal ganglia pathways.
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DOI：
10.1038/nn.3456
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发表时间：
2013-08
影响因子：
25
通讯作者：
Berke, Joshua D.
中科院分区：
文献类型：
--
作者：
Schmidt, Robert;Leventhal, Daniel K.;Mallet, Nicolas;Chen, Fujun;Berke, Joshua D.
Salient cues can prompt the rapid interruption of planned actions. It has been proposed that fast, reactive behavioral inhibition involves specific basal ganglia pathways, and we tested this by comparing activity in multiple rat basal ganglia structures during performance of a stop-signal task. Subthalamic nucleus (STN) neurons showed low-latency responses to Stop cues, irrespective of whether actions were successfully canceled or not. By contrast, neurons downstream in the substantia nigra pars reticulata (SNr) responded to Stop cues only in trials with successful cancellation. Recordings and simulations together indicate that this sensorimotor gating arises from the relative timing of two distinct inputs to neurons in the SNr dorsolateral “core” subregion: cue-related excitation from STN and movement-related inhibition from striatum. Our results support race models of action cancellation, with successful stopping requiring Stop cue information to be transmitted from STN to SNr before increased striatal input creates a point of no return.
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DOI：
10.1523/jneurosci.2192-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Berke JD
通讯作者：
Berke JD
影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
影响因子：
3.4
作者：
BEVAN, MD;BOLAM, JP;CROSSMAN, AR
通讯作者：
CROSSMAN, AR
影响因子：
10.6
作者：
Aron, Adam R.
通讯作者：
Aron, Adam R.
影响因子：
16.2
作者：
Gage, Gregory J.;Stoetzner, Colin R.;Wiltschko, Alexander B.;Berke, Joshua D.
通讯作者：
Berke, Joshua D.