Staying in touch with the endocytic network: The importance of contacts for cholesterol transport.
Staying in touch with the endocytic network: The importance of contacts for cholesterol transport.
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DOI：
10.1111/tra.12726
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发表时间：
2020-05
期刊：
影响因子：
--
通讯作者：
Eden ER
中科院分区：
文献类型：
--
作者：
Martello A;Platt FM;Eden ER
胆固醇稳态对细胞功能和人类健康至关重要。胆固醇在细胞膜中分布不均匀，内吞的膳食胆固醇的再分布在胆固醇稳态的调节中起着关键作用。虽然我们对细胞内饮食胆固醇转运的理解仍然存在差距，但一个高度复杂的途径网络开始出现，通常涉及相互依赖的囊泡和非囊泡转运机制。在过去的十年中，人们对膜接触部位的非囊泡转运和细胞器间通讯的兴趣激增。通过为蛋白质相互作用、信号传导事件、脂质交换和钙通量提供平台，膜接触位点（MCS）现在被认为控制大量脂质的命运，并在内吞运输的调节和协调中发挥核心作用。在这里，我们回顾了MCS在胆固醇从内吞途径输出的多种途径中的作用，并强调了囊泡和非囊泡转运机制之间有趣的相互作用以及与神经退行性疾病的关系。膳食胆固醇从内吞途径转运到内质网是胆固醇稳态的重要步骤，但胆固醇转运的机制尚不完全清楚。内吞和非内吞细胞器的膜之间的接触位点正在成为囊泡和非囊泡胆固醇转运的重要调节剂。在这里，我们回顾目前的理解，这些膜接触网站和它们的重要性，再分配饮食胆固醇从内吞细胞器到其他细胞膜和神经退行性疾病的作用。
Cholesterol homeostasis is critical for cell function and human health. Cholesterol is heterogeneously distributed among cellular membranes, with the redistribution of endocytosed dietary cholesterol playing a pivotal role in the regulation of cholesterol homeostasis. While gaps remain in our understanding of intracellular dietary cholesterol transport, a highly complex network of pathways is starting to emerge, often involving inter‐dependent vesicular and non‐vesicular transport mechanisms. The last decade has seen a surge in interest in non‐vesicular transport and inter‐organellar communication at membrane contact sites. By providing platforms for protein interactions, signalling events, lipid exchange and calcium flux, membrane contact sites (MCS) are now appreciated as controlling the fate of large amounts of lipid and play central roles in the regulation and co‐ordination of endocytic trafficking. Here, we review the role of MCS in multiple pathways for cholesterol export from the endocytic pathway and highlight the intriguing interplay between vesicular and non‐vesicular transport mechanisms and relationship with neurodegenerative disease. Traffic of dietary cholesterol from the endocytic pathway to the ER is an essential step in cholesterol homeostasis but the mechanism of this cholesterol transport is not completely understood. Sites of contact between the membranes of endocytic and non‐endocytic organelles are emerging as important regulators of both vesicular and non‐vesicular cholesterol transport. Here, we review current understanding of these membrane contact sites and their importance in redistributing dietary cholesterol from endocytic organelles to other cellular membranes and roles in neurodegenerative disease.
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影响因子：
11.8
作者：
Eden ER;Sanchez-Heras E;Tsapara A;Sobota A;Levine TP;Futter CE
通讯作者：
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DOI：
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发表时间：
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Eden ER
影响因子：
7.7
作者：
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DOI：
10.1126/science.aag1417
发表时间：
2017-03-24
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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