Development of the major pathways for neurite outgrowth in the chick hindlimb.
Development of the major pathways for neurite outgrowth in the chick hindlimb.
复制标题
雏鸡后肢神经突生长的主要途径的发展。
DOI：
10.1016/0012-1606(85)90360-4
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发表时间：
1985
影响因子：
2.7
通讯作者：
Landmesser,LT
中科院分区：
文献类型：
--
作者：
Tosney,KW;Landmesser,LT
为了阐明机制，可能会控制发展的总体解剖神经模式，运动神经元生长到鸡后肢进行了检查，使用orthograde标记，扫描和透射电子显微镜，和阿尔新蓝染色。结果表明，生长锥并不通过与定向的细胞外原纤维、对齐的间充质细胞、肌节或脉管系统接触来引导。通路不是由无细胞空间或较低细胞密度的通道划定的;然而，密集的间充质可能形成通道生长的屏障。此外，大量的间充质细胞死亡被认为是在神经前。这种细胞死亡可以提供鼓励生长锥前进的空间。通道通常位于沿着被阿尔新蓝染色的区域之间的界面，阿尔新蓝特异性地染色糖胺聚糖，并且生长锥从不穿透强烈染色的区域，例如骨盆带，这是已知的生长障碍。主要的生长锥与间充质细胞形成专门的接触，但主要的接触是神经元间的。有人建议，生长的解剖模式是由优选的基质的分布，最优选的基质是其他神经突。此外，神经突倾向于喜欢松散的间充质而不是致密的间充质或富含糖胺聚糖的区域。
To elucidate mechanisms that may control development of the gross anatomical nerve pattern, motoneuron outgrowth into the chick hindlimb was examined using orthograde labeling, scanning and transmission electron microscopy, and Alcian blue staining. Results show that growth cones are not guided by contact with oriented extracellular fibrils, aligned mesenchyme cells, the myotome, or the vasculature. Pathways are not delineated by cell-free space or channels of lower cell density; however, densely packed mesenchyme may form barriers that channel outgrowth. In addition, abundant mesenchymal cell death was seen at the nerve front. This cell death may provide space that encourages growth cone advancement. Pathways often lie along interfaces between areas that stain darkly and lightly with Alcian blue, which specifically stains glycosaminoglycans, and growth cones never penetrate areas that stain intensely, such as the pelvic girdle, which is known to be a barrier to outgrowth. Leading growth cones form specialized contacts with mesenchyme cells, but the predominant contacts are interneuronal. It is proposed that the anatomical pattern of outgrowth is determined by the distribution of preferred substrata, the most preferred substratum being other neurites. Further, neurites tend to prefer loose mesenchyme to dense mesenchyme or areas rich in glycosaminoglycans.
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