The potential of electrochemistry for the detection of coronavirus-induced infections.
The potential of electrochemistry for the detection of coronavirus-induced infections.
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DOI：
10.1016/j.trac.2020.116081
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Bonanni A
中科院分区：
文献类型：
--
作者：
Lim RRX;Bonanni A
人类冠状病毒（HCoV）对全球环境并不陌生。以往爆发的呼吸道感染症状的病原学归因于不同的冠状病毒株，2019年最新的全球大流行也属于冠状病毒家族。及时发现、有效治疗和未来预防是管理冠状病毒引起的感染的关键所在。除了临床诊断的金标准外，电化学技术在检测不同病毒及其相关抗体和抗原方面也显示出巨大的潜力，显示出高灵敏度和选择性，以及更快的分析时间。本文旨在批判性地回顾多方面的电化学方法，不仅在即时便携式设备的开发中，而且还作为替代检测策略，可以与传统方法相结合，用于检测各种冠状病毒株。冠状病毒感染的电化学生物传感检测方法。用于大规模检测的潜在快速且具有成本效益的护理点诊断。电化学有助于克服金标准诊断所面临的局限性。各种电化学策略的实验方案、优点和缺点。
Human coronaviruses (HCoV) are no stranger to the global environment. The etiology of previous outbreaks with reported symptoms of respiratory tract infections was attributed to different coronavirus strains, with the latest global pandemic in 2019 also belonging to the coronavirus family. Timely detection, effective therapeutics and future prevention are stake key holders in the management of coronavirus-induced infections. Apart from the gold standard clinical diagnostics, electrochemical techniques have also demonstrated their great potentials in the detection of different viruses and their correlated antibodies and antigens, showing high sensitivities and selectivities, and faster times for the analysis. This article aims to critically review the multifaceted electrochemical approaches, not only in the development of point-of-care portable devices but also as alternative detection strategies that can be coupled with traditional methods for the detection of various strains of coronaviruses. Electrochemical biosensing detection methods for coronavirus-induced infections. Potential rapid and cost-effective point-of-care diagnostics for mass testing. Electrochemistry helps to overcome limitations faced by gold standard diagnostics. Experimental schemes, strengths, and drawbacks of various electrochemical strategies.
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