Plasmonic-Photonic Hybrid Configuration on Optical Fiber Tip: Toward Low-Cost and Miniaturized Biosensing Probe
Plasmonic-Photonic Hybrid Configuration on Optical Fiber Tip: Toward Low-Cost and Miniaturized Biosensing Probe
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光纤尖端的等离激元-光子混合配置：走向低成本和小型化生物传感探针
DOI：
10.1016/j.snb.2022.132059
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发表时间：
2022-05
影响因子：
8.4
通讯作者：
Chengjun Huang
中科院分区：
文献类型：
--
作者：
Xin Li;Fei Wang;Xue Wang;Wenjie Zhao;Hongyao Liu;Mingxiao Li;Yang Zhao;Lingqian Zhang;Chengjun Huang
由于无标记和实时生物传感的优点，光纤尖端上的纳米结构等离子体生物传感器吸引了越来越多的关注，作为潜在的即插即用的遥感探针可用于有限的环境。通过自上而下或自下而上的方法在光纤尖端上开发了各种纳米结构。然而，这些等离子体光纤传感器的传感性能和制造成本之间的权衡通常限制了它们的进一步应用。在此背景下，我们提出并系统地研究了一种新的等离子体-光子混合结构，它大大提高了传感性能，简化了制造工艺。集成到光纤尖端上的混合配置由充当光子腔的电介质涂层和充当等离子体纳米结构的分散的Au纳米颗粒组成。通过局域表面等离子体共振与腔干涉模式的耦合，成功激发了混合等离子体-光子共振，并证明其具有灵敏度高、稳定性好、共振频率可精确调谐等特点。最后，作为生物传感的概念验证，我们通过实验证明，所提出的光纤传感器可以实现实时监测纳摩尔浓度下的生物分子结合相互作用，证实了等离子体光子配置在开发小型化高性能传感探针中的潜力。·基于等离子体共振与干涉耦合的新型等离子体-光子结构光纤传感器。·使用聚对二甲苯-C沉积和Au纳米颗粒的共聚物辅助组装的可扩展制造。·灵敏度和再现性与自上而下的纳米制造传感器一样高。·可精确调谐的共振波长，适用于特定的生化传感应用。
Owing to the label-free and real-time biosensing advantages, the nanostructured plasmonic biosensors on optical fiber tips have attracted increasing attention as potential plug-and-play remote sensing probes available for limited environments. Various nanostructures have been developed by either top-down or bottom-up approaches on optical fiber tips. However, a trade-off between the sensing performance and manufacturing cost of these plasmonic fiber-optic sensors usually limited their further application. In this context, we propose and systematically investigate a novel plasmonic-photonic hybrid configuration, which dramatically boosts the sensing performance and simplifies the fabrication process. The hybrid configuration integrated onto the fiber tip consists of a dielectric coating acting as the photonic cavity and dispersed Au nanoparticles serving as the plasmonic nanostructures. As a result of the coupling between localized surface plasmon resonance and the cavity interference mode, a hybrid plasmonic-photonic resonance is successfully excited and proved to have serval unique features including enhanced sensitivity, high stability, and precise tunability of the resonance frequencies. Finally, as a proof-of-concept for biosensing, we experimentally demonstrate that the proposed fiber-optic sensors can achieve real-time monitoring of the biomolecular binding interactions at nanomolar concentration, confirming the potential of the plasmonic-photonic configuration in developing miniaturized high-performance sensing probes. • A novel plasmonic-photonic configurated fiber-optic sensor based on the coupling between plasmon resonance and interference. • Scalable Fabrication using parylene-C deposition and copolymer-assisted assembly of Au nanoparticles. • Sensitivity and reproducibility as high as top-down nanofabricated sensors. • Precisely tunable resonance wavelengths for specific biochemical sensing applications.
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DOI：
10.3390/s16091460
发表时间：
2016-09-09
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Fang YL;Wang CT;Chiang CC
通讯作者：
Chiang CC
DOI：
10.1039/c7an00249a
发表时间：
2017-06-07
期刊：
The Analyst
影响因子：
--
作者：
Kaye S;Zeng Z;Sanders M;Chittur K;Koelle PM;Lindquist R;Manne U;Lin Y;Wei J
通讯作者：
Wei J
影响因子：
5.4
作者：
Samuel R. Anderson;A. O’Mullane;E. Della Gaspera;R. Ramanathan;V. Bansal
通讯作者：
Samuel R. Anderson;A. O’Mullane;E. Della Gaspera;R. Ramanathan;V. Bansal
DOI：
10.3390/s141018701
发表时间：
2014-10-09
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Ortega-Mendoza JG;Padilla-Vivanco A;Toxqui-Quitl C;Zaca-Morán P;Villegas-Hernández D;Chávez F
通讯作者：
Chávez F
影响因子：
8.9
作者：
Lu, Mengdi;Zhu, Hu;Masson, Jean-Francois
通讯作者：
Masson, Jean-Francois