Prevalence of CKD, Diabetes, and Hypertension in Rural Tanzania.
Prevalence of CKD, Diabetes, and Hypertension in Rural Tanzania.
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DOI：
10.1016/j.ekir.2018.04.006
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发表时间：
2018-07
影响因子：
6
通讯作者：
Sweat MD
中科院分区：
文献类型：
--
作者：
Ploth DW;Mbwambo JK;Fonner VA;Horowitz B;Zager P;Schrader R;Fredrick F;Laggis C;Sweat MD
慢性肾脏病（CKD）、糖尿病和高血压在东非非传染性疾病（NCD）构成的日益严重的公共卫生挑战中发挥着不成比例的作用。这些非传染性疾病的影响可能在筛查和治疗设施有限的农村地区构成最大的挑战，尽管坦桑尼亚农村地区缺乏对这些疾病的准确流行率估计。CKD、糖尿病和高血压的患病率是从居住在坦桑尼亚农村地区Kisarawe的2个社区的成年人（n = 739）的概率样本中估计的。在同意后，参与者在家中进行研究。获得糖化血红蛋白和血压的随机护理点（POC）测量值。在POC抽取并在Muhimbili国立大学测量的血清肌酐用于使用慢性肾脏病流行病学协作组（CKD-EPI）方程计算估计的肾小球滤过率。中位年龄为35岁（四分位距为25 - 45岁）。总体而言，CKD III、IV和V期的合并患病率为12.4%（95%置信区间[CI] = 10.2 - 14.8）。令人惊讶的是，CKD V期的患病率（3.0%; 95% CI = 2.1 - 4.4）在最年轻的年龄组（18 - 36岁）中很高。高血压前期和高血压的患病率估计值分别为38.0%（95% CI = 34.6 - 41.5）和19.9%（95% CI = 17.1 - 22.9）。糖尿病前期和糖尿病的患病率估计值分别为25.7%（95%CI = 22.6 - 29.1）和14.8%（95%CI = 12.4 - 17.6）。尽管这项试点研究的样本量相对较小，但CKD、糖尿病和高血压的患病率估计值高于我们基于坦桑尼亚先前估计值的预期。CKD与糖尿病或高血压无显著相关性，提示可能存在替代因果关系。
Chronic kidney disease (CKD), diabetes, and hypertension play a disproportionate role in the growing public health challenge posed by noncommunicable diseases (NCDs) in East Africa. The impact of these NCDs may pose the greatest challenge in rural areas with limited screening and treatment facilities, although precise prevalence estimates of these conditions in rural Tanzania are lacking. The prevalence of CKD, diabetes, and hypertension, were estimated from a probability sample of adults (n = 739) residing in 2 communities within Kisarawe, a rural district of Tanzania. Following consent, participants were studied in their homes. Random point-of-care (POC) measures of glycosylated hemoglobin and blood pressure, were obtained. Serum creatinine, drawn at the POC and measured at Muhimbili National University, was used to calculate estimated glomerular filtration rate with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The median age was 35 years (interquartile range 25−45 years). Overall the pooled prevalence for CKD stages III, IV, and V was 12.4% (95% confidence interval [CI] = 10.2−14.8). Surprisingly, the prevalence of CKD stage V (3.0%; 95% CI = 2.1−4.4) was high among the youngest age group (18−36 years). The prevalence estimates for prehypertension and hypertension were 38.0% (95% CI = 34.6−41.5) and 19.9% (95% CI = 17.1−22.9), respectively. The prevalence estimates for prediabetes and diabetes were 25.7% (95% CI = 22.6−29.1) and 14.8% (95% CI = 12.4−17.6), respectively. Although this pilot study had a relatively small sample size, the prevalence estimates for CKD, diabetes, and hypertension were higher than we expected based on previous estimates from Tanzania. CKD was not significantly associated with diabetes or hypertension, suggesting the possibility of an alternative causality.
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影响因子：
9.3
作者：
Kavishe B;Biraro S;Baisley K;Vanobberghen F;Kapiga S;Munderi P;Smeeth L;Peck R;Mghamba J;Mutungi G;Ikoona E;Levin J;Bou Monclús MA;Katende D;Kisanga E;Hayes R;Grosskurth H
通讯作者：
Grosskurth H
影响因子：
5.1
作者：
Mayega, Roy William;Guwatudde, David;Ostenson, Claes-Goran
通讯作者：
Ostenson, Claes-Goran
影响因子：
168.9
作者：
Jha, Vivekanand;Garcia-Garcia, Guillermo;Yang, Chih-Wei
通讯作者：
Yang, Chih-Wei
影响因子：
34.3
作者：
Peck, Robert;Mghamba, Janneth;Vanobberghen, Fiona;Kavishe, Bazil;Rugarabamu, Vivian;Smeeth, Liam;Hayes, Richard;Grosskurth, Heiner;Kapiga, Saidi
通讯作者：
Kapiga, Saidi
影响因子：
13.2
作者：
Coresh, J;Astor, BC;Levey, AS
通讯作者：
Levey, AS